Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VBH

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28683-0

PUBLICATION DATE

April 6, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 20 V30 N-term Van der Waals
Peptide 20 V30 N-term polar (hydrogen bond with backbone)
Peptide 20 S31 N-term polar (hydrogen bond with backbone)
Peptide 20 S31 N-term Van der Waals
Peptide 20 L32 N-term polar (hydrogen bond with backbone)
Peptide 20 L32 N-term Van der Waals
Peptide 20 T35 N-term Van der Waals
Peptide 20 W39 N-term Van der Waals
Peptide 20 W39 N-term aromatic (face-to-edge)
Peptide 20 D67 N-term Van der Waals
Peptide 20 D67 N-term polar (hydrogen bond with backbone)
Peptide 20 E68 N-term polar (charge-assisted hydrogen bond)
Peptide 20 Y69 N-term Van der Waals
Peptide 20 Y69 N-term hydrophobic
Peptide 20 Y88 N-term Van der Waals
Peptide 20 Y88 N-term hydrophobic
Peptide 20 P90 N-term Van der Waals
Peptide 20 P90 N-term hydrophobic
Peptide 20 W91 N-term hydrophobic
Peptide 20 W91 N-term Van der Waals
Peptide 20 R121 N-term polar (charge-assisted hydrogen bond)
Peptide 20 L123 N-term Van der Waals
Peptide 20 L123 N-term hydrophobic
Peptide 20 E128 N-term Van der Waals
Peptide 20 E138 1.33x33 TM1 Van der Waals
Peptide 20 L141 1.36x36 TM1 hydrophobic
Peptide 20 L141 1.36x36 TM1 Van der Waals
Peptide 20 L142 1.37x37 TM1 hydrophobic
Peptide 20 L142 1.37x37 TM1 Van der Waals
Peptide 20 Y145 1.40x40 TM1 hydrophobic
Peptide 20 Y145 1.40x40 TM1 Van der Waals
Peptide 20 I146 1.41x41 TM1 Van der Waals
Peptide 20 I146 1.41x41 TM1 hydrophobic
Peptide 20 Y148 1.43x43 TM1 aromatic (edge-to-face)
Peptide 20 Y148 1.43x43 TM1 Van der Waals
Peptide 20 T149 1.44x44 TM1 Van der Waals
Peptide 20 V150 1.45x45 TM1 hydrophobic
Peptide 20 V150 1.45x45 TM1 Van der Waals
Peptide 20 Y152 1.47x47 TM1 Van der Waals
Peptide 20 A153 1.48x48 TM1 Van der Waals
Peptide 20 A153 1.48x48 TM1 hydrophobic
Peptide 20 L154 1.49x49 TM1 hydrophobic
Peptide 20 L154 1.49x49 TM1 Van der Waals
Peptide 20 V194 2.64x64 TM2 Van der Waals
Peptide 20 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Peptide 20 L201 2.71x71 TM2 hydrophobic
Peptide 20 L201 2.71x71 TM2 Van der Waals
Peptide 20 K202 2.72x72 TM2 Van der Waals
Peptide 20 Y205 ECL1 hydrophobic
Peptide 20 Y205 ECL1 Van der Waals
Peptide 20 Q210 ECL1 Van der Waals
Peptide 20 Q234 3.37x37 TM3 polar (hydrogen bond)
Peptide 20 T298 45.52x52 ECL2 Van der Waals
Peptide 20 R299 ECL2 polar (charge-assisted hydrogen bond)
Peptide 20 N300 ECL2 polar (hydrogen bond with backbone)
Peptide 20 N300 ECL2 Van der Waals
Peptide 20 N300 ECL2 polar (hydrogen bond)
Peptide 20 W306 5.36x37 TM5 Van der Waals
Peptide 20 W306 5.36x37 TM5 polar (hydrogen bond)
Peptide 20 D372 ECL3 polar (charge-assisted hydrogen bond)
Peptide 20 R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide 20 L384 7.39x38 TM7 hydrophobic
Peptide 20 L384 7.39x38 TM7 Van der Waals
Peptide 20 L388 7.43x42 TM7 hydrophobic
Peptide 20 L388 7.43x42 TM7 Van der Waals

Ligands

Peptide 20

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x33 1.37x37 L142
1x36 1.40x40 Y145
1x37 1.41x41 I146
1x39 1.43x43 Y148
1x40 1.44x44 T149
1x41 1.45x45 V150
1x43 1.47x47 Y152
1x44 1.48x48 A153
1x45 1.49x49 L154
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x64 2.71x71 L201
2x65 2.72x72 K202
TM3
3x33 3.37x37 Q234
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x38 7.43x42 L388