Structure information

FPR1

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VFX

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-32822-Y

PUBLICATION DATE

Sept. 21, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide agonist fMet-Ile-Phe-Leu F102 3.29x29 TM3 hydrophobic
Peptide agonist fMet-Ile-Phe-Leu D106 3.33x33 TM3 polar (charge-assisted hydrogen bond)
Peptide agonist fMet-Ile-Phe-Leu L109 3.36x36 TM3 Van der Waals
Peptide agonist fMet-Ile-Phe-Leu L109 3.36x36 TM3 hydrophobic
Peptide agonist fMet-Ile-Phe-Leu F110 3.37x37 TM3 Van der Waals
Peptide agonist fMet-Ile-Phe-Leu F110 3.37x37 TM3 hydrophobic
Peptide agonist fMet-Ile-Phe-Leu T177 45.51x51 ECL2 Van der Waals
Peptide agonist fMet-Ile-Phe-Leu F178 45.52x52 ECL2 hydrophobic
Peptide agonist fMet-Ile-Phe-Leu F178 45.52x52 ECL2 Van der Waals
Peptide agonist fMet-Ile-Phe-Leu R201 5.38x39 TM5 polar (charge-assisted hydrogen bond)
Peptide agonist fMet-Ile-Phe-Leu R205 5.42x43 TM5 polar (charge-assisted hydrogen bond)
Peptide agonist fMet-Ile-Phe-Leu Y257 6.51x51 TM6 polar (hydrogen bond)
Peptide agonist fMet-Ile-Phe-Leu Y257 6.51x51 TM6 polar (hydrogen bond)
Peptide agonist fMet-Ile-Phe-Leu V283 7.35x34 TM7 Van der Waals
Peptide agonist fMet-Ile-Phe-Leu V283 7.35x34 TM7 hydrophobic

Ligands

Peptide agonist fMet-Ile-Phe-Leu

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Residue Diagrams

G N G L V G L V F T V A F V L Y T I I D 1 L N L A V A D F C F T S T L P F F M V R 2 L A I L F V S G F L N I D V I T F V F K 3 A K K V I I G P W V M A L L L T L P V 4 Y S V A V I S M P A S F G I I F R I I G R 5 S F V A A A F F L C W S P Y Q V V A L I 6 M P N L C S N F F A L A S T V D V A I 7
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ICL1 T H ICL1ECL1 G H W P F ECL1ICL2 P V W T Q N H R ICL2ECL2 T T V P G K T G T V A C T F N F S P W T N ECL2ICL3 L I K S ICL3ECL3 I R E L L Q G M ECL3N-term M E T N S S L P T N I S G G T P A V N-termC-term P A S L E R A L T E D S T Q T S D T A T N S T L P S A E V E L Q A K C-term S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H T V S L A K K V I I G P W V M A L L L T L P V I I R V D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D L I H F R E R A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
FPR1
TM3
3x29 3.29x29 F102
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x39 5.38x39 R201
5x43 5.42x43 R205
TM6
6x51 6.51x51 Y257
TM7
7x34 7.35x34 V283