Structure information

MT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VGY

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-022-28111-3

PUBLICATION DATE

March 2, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2-iodo-melatonin M107 3.32x32 TM3 hydrophobic
2-iodo-melatonin I112 3.37x37 TM3 hydrophobic
2-iodo-melatonin F179 45.52x52 ECL2 aromatic (edge-to-face)
2-iodo-melatonin V191 5.42x43 TM5 hydrophobic
2-iodo-melatonin W251 6.48x48 TM6 hydrophobic
2-iodo-melatonin N255 6.52x52 TM6 Van der Waals
2-iodo-melatonin N255 6.52x52 TM6 polar (hydrogen bond)

Ligands

2-iodo-melatonin

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Residue Diagrams

L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x32 3.32x32 M107
3x37 3.37x37 I112
ECL2
45x52 45.52x52 F179
TM5
5x43 5.42x43 V191
TM6
6x48 6.48x48 W251
6x52 6.52x52 N255