Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7VIF

SPECIES

Homo sapiens

RESOLUTION

2.830

PREFERRED CHAIN

F

REFERENCE

10.1073/PNAS.2117716119

PUBLICATION DATE

Sept. 28, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(S)-FTY720-phosphate Y29 N-term polar (hydrogen bond)
(S)-FTY720-phosphate N101 2.60x60 TM2 Van der Waals
(S)-FTY720-phosphate N101 2.60x60 TM2 polar (hydrogen bond)
(S)-FTY720-phosphate S105 2.64x64 TM2 Van der Waals
(S)-FTY720-phosphate G106 23.47x47 ECL1 Van der Waals
(S)-FTY720-phosphate G106 23.47x47 ECL1 polar (hydrogen bond with backbone)
(S)-FTY720-phosphate T109 23.50x50 ECL1 Van der Waals
(S)-FTY720-phosphate R120 3.28x28 TM3 Van der Waals
(S)-FTY720-phosphate E121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
(S)-FTY720-phosphate F125 3.33x33 TM3 hydrophobic
(S)-FTY720-phosphate F125 3.33x33 TM3 Van der Waals
(S)-FTY720-phosphate L128 3.36x36 TM3 hydrophobic
(S)-FTY720-phosphate L128 3.36x36 TM3 Van der Waals
(S)-FTY720-phosphate S129 3.37x37 TM3 Van der Waals
(S)-FTY720-phosphate F210 5.47x47 TM5 hydrophobic
(S)-FTY720-phosphate W269 6.48x48 TM6 hydrophobic
(S)-FTY720-phosphate W269 6.48x48 TM6 Van der Waals
(S)-FTY720-phosphate L272 6.51x51 TM6 hydrophobic
(S)-FTY720-phosphate L272 6.51x51 TM6 Van der Waals
(S)-FTY720-phosphate L297 7.39x38 TM7 hydrophobic
(S)-FTY720-phosphate L297 7.39x38 TM7 Van der Waals

Ligands

(S)-FTY720-phosphate

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
2x64 2.64x64 S105
ECL1
23x47 23.47x47 G106
23x50 23.50x50 T109
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
TM5
5x47 5.47x47 F210
TM6
6x48 6.48x48 W269
6x51 6.51x51 L272
TM7
7x38 7.39x38 L297