Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7VVN

SPECIES

Homo sapiens

RESOLUTION

3.800

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2022.07.003

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
teriparatide F184 1.36x36 TM1 hydrophobic
teriparatide Q364 5.40x40 TM5 polar (hydrogen bond)
teriparatide I367 5.43x43 TM5 Van der Waals
teriparatide I367 5.43x43 TM5 hydrophobic
teriparatide L368 5.44x44 TM5 hydrophobic
teriparatide L368 5.44x44 TM5 Van der Waals
teriparatide F424 6.56x56 TM6 polar (hydrogen bond with backbone)
teriparatide F424 6.56x56 TM6 Van der Waals
teriparatide M425 6.57x57 TM6 Van der Waals
teriparatide M425 6.57x57 TM6 polar (hydrogen bond with backbone)
teriparatide T427 ECL3 Van der Waals
teriparatide T427 ECL3 polar (hydrogen bond with backbone)
teriparatide T430 ECL3 Van der Waals
teriparatide E444 7.42x41 TM7 polar (charge-assisted hydrogen bond)
teriparatide M445 7.43x42 TM7 Van der Waals

Ligands

teriparatide

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x32 1.36x36 F184
TM5
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x51 6.56x56 F424
6x52 6.57x57 M425
TM7
7x37 7.42x41 E444
7x38 7.43x42 M445