Structure information

TRH1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7X1T

SPECIES

Homo sapiens

RESOLUTION

3.260

PREFERRED CHAIN

A

REFERENCE

10.1038/S41422-022-00646-6

PUBLICATION DATE

Aug. 31, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
taltirelin Y106 3.33x33 TM3 polar (hydrogen bond)
taltirelin Y106 3.33x33 TM3 Van der Waals
taltirelin I109 3.36x36 TM3 Van der Waals
taltirelin C179 45.50x50 ECL2 polar (hydrogen bond with backbone)
taltirelin C179 45.50x50 ECL2 Van der Waals
taltirelin Y181 45.52x52 ECL2 Van der Waals
taltirelin Y181 45.52x52 ECL2 aromatic (face-to-edge)
taltirelin Y181 45.52x52 ECL2 polar (hydrogen bond)
taltirelin R185 5.32x32 TM5 polar (charge-assisted hydrogen bond)
taltirelin Y282 6.51x51 TM6 polar (hydrogen bond)
taltirelin Y282 6.51x51 TM6 polar (hydrogen bond)
taltirelin Y282 6.51x51 TM6 Van der Waals
taltirelin V286 6.55x55 TM6 Van der Waals
taltirelin N289 6.58x58 TM6 polar (hydrogen bond)
taltirelin N289 6.58x58 TM6 Van der Waals
taltirelin L302 7.35x34 TM7 hydrophobic
taltirelin L302 7.35x34 TM7 Van der Waals
taltirelin R306 7.39x38 TM7 polar (charge-assisted hydrogen bond)
taltirelin Y310 7.43x42 TM7 polar (hydrogen bond)
taltirelin Y310 7.43x42 TM7 Van der Waals

Ligands

taltirelin

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Residue Diagrams

I N G V I G L G C I I L V L L I T V V Q 1 V S L A V A D L M V L A V A G L P N I T D 2 A T I S C S S A N I G L Y Q L Y T I C L 3 A K K I I I F V W A F T S L Y C M L W F 4 Y L V T A L I M P V V Y F V G F D M L Y 5 A V V V I L F A L L W M P Y R T L V V V 6 V P N I A S N L Y I C I R C F L L F W 7
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ICL1 K H M R ICL1ECL1 G S W V Y ECL1ICL2 P I K A Q F L C ICL2ECL2 D L N I S T Y K D A I V I S C G Y K ECL2ICL3 N S K T W K N D S T H Q N T N L N V N T S N R C F ICL3ECL3 S S P F Q ECL3N-term M E N E T V S E L N Q T Q L Q P R A V V A N-termC-term C K Q K P T E K P A N Y S V A L N Y S V I K E S D H F S T E L D D I T V T D T Y L S A T K V S F D D T C L A S E V S F S Q S C-term L E Y Q V V T I L L V L I I C G L G I V G N I M V V L V V M R T T P T N C Y L V S L A V A D L M V L V A A G L P N I T D S I Y G Y V G C L C I T Y L Q Y L G I N A S S C S I T A F T I E R Y I A I C H T F S R A K K I I I F V W A F T S L Y C M L W F F L L I S R N Y Y S P I Y L M D F G V F Y V V P M I L A T V L Y G F I A R I L F L N P I P S D P K E N S T V S S R K Q V T K M L A V V V I L F A L L W M P Y R T L V V V N S F L E N W F L L F C R I C I Y L N S A I N P V I Y N L M S Q K F R K F R A A L C N
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Residue Table


GPCRdb(A)
GPCRdb(A)
TRH1 receptor
TM3
3x33 3.33x33 Y106
3x36 3.36x36 I109
ECL2
45x50 45.50x50 C179
45x52 45.52x52 Y181
TM5
5x32 5.32x32 R185
TM6
6x51 6.51x51 Y282
6x55 6.55x55 V286
6x58 6.58x58 N289
TM7
7x34 7.35x34 L302
7x38 7.39x38 R306
7x42 7.43x42 Y310