Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7X2D

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

F

REFERENCE

PUBLICATION DATE

June 15, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TAVAPADON K81 2.61x60 TM2 polar (charge-assisted hydrogen bond)
TAVAPADON W99 3.28x28 TM3 Van der Waals
TAVAPADON W99 3.28x28 TM3 aromatic (edge-to-face)
TAVAPADON V100 3.29x29 TM3 hydrophobic
TAVAPADON V100 3.29x29 TM3 Van der Waals
TAVAPADON D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
TAVAPADON I104 3.33x33 TM3 Van der Waals
TAVAPADON I104 3.33x33 TM3 hydrophobic
TAVAPADON S107 3.36x36 TM3 Van der Waals
TAVAPADON T108 3.37x37 TM3 Van der Waals
TAVAPADON C186 45.50x50 ECL2 Van der Waals
TAVAPADON C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
TAVAPADON D187 45.51x51 ECL2 Van der Waals
TAVAPADON S188 45.52x52 ECL2 polar (hydrogen bond with backbone)
TAVAPADON S188 45.52x52 ECL2 Van der Waals
TAVAPADON L190 ECL2 hydrophobic
TAVAPADON L190 ECL2 Van der Waals
TAVAPADON S198 5.42x43 TM5 polar (hydrogen bond)
TAVAPADON W285 6.48x48 TM6 hydrophobic
TAVAPADON W285 6.48x48 TM6 Van der Waals
TAVAPADON F288 6.51x51 TM6 hydrophobic
TAVAPADON F288 6.51x51 TM6 Van der Waals
TAVAPADON F289 6.52x52 TM6 Van der Waals
TAVAPADON F289 6.52x52 TM6 hydrophobic
TAVAPADON N292 6.55x55 TM6 Van der Waals
TAVAPADON V317 7.39x38 TM7 Van der Waals
TAVAPADON V317 7.39x38 TM7 hydrophobic

Ligands

TAVAPADON

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM2
2x60 2.61x60 K81
TM3
3x28 3.28x28 W99
3x29 3.29x29 V100
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 T108
ECL2
45x50 45.50x50 C186
45x51 45.51x51 D187
45x52 45.52x52 S188
TM5
5x43 5.42x43 S198
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x38 7.39x38 V317