Structure information

SST4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XMS

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00679-X

PUBLICATION DATE

Aug. 3, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN V103 2.60x60 TM2 hydrophobic
SOMATOSTATIN D126 3.32x32 TM3 polar (charge-assisted hydrogen bond)
SOMATOSTATIN M130 3.36x36 TM3 Van der Waals
SOMATOSTATIN P189 ECL2 polar (hydrogen bond with backbone)
SOMATOSTATIN P189 ECL2 Van der Waals
SOMATOSTATIN A190 ECL2 Van der Waals
SOMATOSTATIN A190 ECL2 polar (hydrogen bond with backbone)
SOMATOSTATIN R191 ECL2 Van der Waals
SOMATOSTATIN N199 45.51x51 ECL2 polar (hydrogen bond)
SOMATOSTATIN N199 45.51x51 ECL2 Van der Waals
SOMATOSTATIN L200 45.52x52 ECL2 hydrophobic
SOMATOSTATIN L200 45.52x52 ECL2 Van der Waals
SOMATOSTATIN W202 ECL2 aromatic (edge-to-face)
SOMATOSTATIN W202 ECL2 Van der Waals
SOMATOSTATIN S208 5.35x36 TM5 Van der Waals
SOMATOSTATIN F211 5.38x39 TM5 hydrophobic
SOMATOSTATIN T215 5.42x43 TM5 Van der Waals
SOMATOSTATIN Q279 6.55x55 TM6 Van der Waals
SOMATOSTATIN N282 6.58x58 TM6 Van der Waals
SOMATOSTATIN L283 6.59x59 TM6 hydrophobic
SOMATOSTATIN L283 6.59x59 TM6 Van der Waals
SOMATOSTATIN T286 ECL3 polar (hydrogen bond)
SOMATOSTATIN T286 ECL3 Van der Waals
SOMATOSTATIN N293 7.35x34 TM7 Van der Waals
SOMATOSTATIN L297 7.39x38 TM7 hydrophobic
SOMATOSTATIN Y301 7.43x42 TM7 Van der Waals

Ligands

SOMATOSTATIN

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Residue Diagrams

A N G V L G V L C V L A Y I C Q I A V M 1 L N L A V A D E L F M L S V P F V A S S 2 V T L C F V S T F M N L G D V S L V A R 3 A K L I N L G V W L A S L L V T L P I 4 Y C L G I A L V P L L F G L L F T Y V V F 5 L M V V V V F V L C W M P F Y V V Q L L 6 I P N A C S N A Y S L I L S V H N V T 7
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ICL1 A K M K ICL1ECL1 R H W P F ECL1ICL2 P L R A A T Y R ICL2ECL2 D T R P A R G G Q A V A C N L Q W P ECL2ICL3 A L R A G ICL3ECL3 T S L D ECL3N-term M S A P S T L P P G G E E G L G T A W P S A A N A S S A P A E A E E A V A G P G D A R N-termC-term L R C C L L E G A G G A E E E P L D Y Y A T A L K S K G G A G C M C P P L P C Q Q E A L Q P E P G R K R I P L T R T T T F C-term A A G M V A I Q C I Y A L V C L V G L V G N A L V I F V I L R Y T A T N I Y L L N L A V A D E L F M L S V P F V A S S A A L G S V L C R A V L S V D G L N M F T S V F C L T V L S V D R Y V A V V H R P S V A K L I N L G V W L A S L L V T L P I A I F A H P A W S A V F V V Y T F L L G F L L P V L A I G L C Y L L I V G K M R A V W Q Q R R R S E K K I T R L V L M V V V V F V L C W M P F Y V V Q L L N L F V A T V N H V S L I L S Y A N S C A N P I L Y G F L S D N F Q R F R R F V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST4 receptor
TM2
2x60 2.60x60 V103
TM3
3x32 3.32x32 D126
3x36 3.36x36 M130
ECL2
45x51 45.51x51 N199
45x52 45.52x52 L200
TM5
5x36 5.35x36 S208
5x39 5.38x39 F211
5x43 5.42x43 T215
TM6
6x55 6.55x55 Q279
6x58 6.58x58 N282
6x59 6.59x59 L283
TM7
7x34 7.35x34 N293
7x38 7.39x38 L297
7x42 7.43x42 Y301