Structure information

CCK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XOU

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00420-3

PUBLICATION DATE

July 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CCK-8 N98 2.61x60 TM2 Van der Waals
CCK-8 N98 2.61x60 TM2 polar (hydrogen bond)
CCK-8 P101 2.64x63 TM2 Van der Waals
CCK-8 N102 2.65x64 TM2 Van der Waals
CCK-8 K105 2.68x67 TM2 Van der Waals
CCK-8 F107 23.50x50 ECL1 Van der Waals
CCK-8 M121 3.32x32 TM3 hydrophobic
CCK-8 M121 3.32x32 TM3 Van der Waals
CCK-8 G122 3.33x33 TM3 Van der Waals
CCK-8 V125 3.36x36 TM3 Van der Waals
CCK-8 V125 3.36x36 TM3 hydrophobic
CCK-8 Y179 4.63x64 TM4 Van der Waals
CCK-8 T186 ECL2 Van der Waals
CCK-8 T186 ECL2 polar (hydrogen bond with backbone)
CCK-8 M195 ECL2 Van der Waals
CCK-8 M195 ECL2 hydrophobic
CCK-8 C196 45.50x50 ECL2 Van der Waals
CCK-8 R197 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
CCK-8 I329 6.51x51 TM6 hydrophobic
CCK-8 I329 6.51x51 TM6 Van der Waals
CCK-8 A332 6.54x54 TM6 hydrophobic
CCK-8 A332 6.54x54 TM6 Van der Waals
CCK-8 N333 6.55x55 TM6 Van der Waals
CCK-8 R336 6.58x58 TM6 Van der Waals
CCK-8 E344 ECL3 Van der Waals
CCK-8 L347 ECL3 hydrophobic
CCK-8 L347 ECL3 Van der Waals
CCK-8 S348 ECL3 Van der Waals
CCK-8 I352 7.35x34 TM7 hydrophobic
CCK-8 I352 7.35x34 TM7 Van der Waals
CCK-8 L356 7.39x38 TM7 hydrophobic
CCK-8 L356 7.39x38 TM7 Van der Waals
CCK-8 Y360 7.43x42 TM7 polar (hydrogen bond)

Ligands

CCK-8

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Residue Diagrams

T N G L V S L L F I L S Y L L I Q V A P 1 L S L A V S D L M L C F L C M P F N L I P 2 A V L N F T S V S V S T G M F Y T T T K 3 A L K V I A A T W C L S F T I M T P Y 4 Y A V M M V I G P I L F L I L L L F T H W 5 I V I V V L F F L C W M P I F S A N A W 6 I P N V C S S T Y S L L L I F S I P T 7
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ICL1 K R M R ICL1ECL1 D F I F ECL1ICL2 P L Q S R V W Q ICL2ECL2 N L V P F T K N N N Q T A N M C R F L L P ECL2ICL3 Q K K S A K E R K P S T T S S G K Y E D S D G C Y L Q K T R P P R K L E L R Q L S T G S S S R A N R I R S N S ICL3ECL3 T A S A E R R L S ECL3N-term M D V V D S L L V N G S N I T P P C E L G L E N E T L F C L D Q P R P S K E N-termC-term P G P P G A R G E V G E E E E G G T T G A S L S R F S Y S H M S A S V P P Q C-term W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F M A C P N F R L G T F P C
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK1 receptor
TM2
2x60 2.61x60 N98
2x63 2.64x63 P101
2x64 2.65x64 N102
2x67 2.68x67 K105
ECL1
23x50 23.50x50 F107
TM3
3x32 3.32x32 M121
3x33 3.33x33 G122
3x36 3.36x36 V125
TM4
4x64 4.63x64 Y179
ECL2
45x50 45.50x50 C196
45x51 45.51x51 R197
TM6
6x51 6.51x51 I329
6x54 6.54x54 A332
6x55 6.55x55 N333
6x58 6.58x58 R336
TM7
7x34 7.35x34 I352
7x38 7.39x38 L356
7x42 7.43x42 Y360