Structure information

Y2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YON

SPECIES

Homo sapiens

RESOLUTION

2.950

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2022.11.010

PUBLICATION DATE

March 22, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide YY L40 N-term hydrophobic
Peptide YY T107 2.61x60 TM2 polar (hydrogen bond)
Peptide YY T107 2.61x60 TM2 polar (hydrogen bond with backbone)
Peptide YY T107 2.61x60 TM2 polar (hydrogen bond)
Peptide YY Y110 2.64x63 TM2 Van der Waals
Peptide YY Y110 2.64x63 TM2 hydrophobic
Peptide YY T111 2.65x64 TM2 polar (hydrogen bond)
Peptide YY T111 2.65x64 TM2 Van der Waals
Peptide YY Q130 3.32x32 TM3 Van der Waals
Peptide YY I192 ECL2 Van der Waals
Peptide YY E193 ECL2 Van der Waals
Peptide YY E193 ECL2 polar (hydrogen bond with backbone)
Peptide YY I194 ECL2 Van der Waals
Peptide YY I194 ECL2 hydrophobic
Peptide YY T204 45.51x51 ECL2 polar (hydrogen bond)
Peptide YY T204 45.51x51 ECL2 Van der Waals
Peptide YY E205 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Peptide YY Y219 5.38x39 TM5 hydrophobic
Peptide YY Y219 5.38x39 TM5 Van der Waals
Peptide YY S220 5.39x40 TM5 Van der Waals
Peptide YY Q288 6.55x55 TM6 polar (hydrogen bond)
Peptide YY Q288 6.55x55 TM6 polar (hydrogen bond)
Peptide YY V291 6.58x58 TM6 Van der Waals
Peptide YY S295 ECL3 Van der Waals
Peptide YY L298 ECL3 Van der Waals
Peptide YY L298 ECL3 polar (hydrogen bond with backbone)
Peptide YY D299 ECL3 Van der Waals
Peptide YY L300 ECL3 Van der Waals
Peptide YY K301 ECL3 Van der Waals
Peptide YY Y303 7.31x30 TM7 hydrophobic
Peptide YY Y303 7.31x30 TM7 Van der Waals
Peptide YY K304 7.32x31 TM7 Van der Waals
Peptide YY F307 7.35x34 TM7 hydrophobic
Peptide YY F307 7.35x34 TM7 Van der Waals
Peptide YY H311 7.39x38 TM7 polar (hydrogen bond)

Ligands

Peptide YY

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Residue Diagrams

S N G I V G L L I I S C Y A L I L V V Q 1 A N L A V A D L L V N L T C L P F T L T Y 2 V T L T I T S V Q V A L G Q A Y P V L H 3 S F L I I G L A W G I S A L L A S P L 4 Y S F S I I G L P L V Y L I L L S S L S Y 5 V C V V V V F A V S W L P L H A F Q L A 6 L P N A F T S C M A I I H F V T F I L 7
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ICL1 K S M R ICL1ECL1 E W K M ECL1ICL2 H L E S K I ICL2ECL2 E Y S L I E I I P D F E I V A C T E K W P G E E K ECL2ICL3 A A ICL3ECL3 S Q V L ECL3N-term M G P I G A E A D E N Q T V E E M K V E Q Y G P Q T T P R G E L V P D P E P E L I D S T K L I N-termC-term L D A I H S E V S V T F K A K K N L E V R K N S G P N D S F T E A T N V C-term E V Q V V L I L A Y C S I I L L G V I G N S L V I H V V I K F T V T N F F I A N L A V A D L L V N T L C L P F T L T Y T L M G G P V L C H L V P Y A Q G L A V Q V S T I T L T V I A L D R H R C I V Y S K R I S F L I I G L A W G I S A L L A S P L A I F R S I Y G T V Y S L S S L L I L Y V L P L G I I S F S Y T R I W S K L K N H V S P G N D H Y H Q R R Q K T T K M L V C V V V V F A V S W L P L H A F Q L A V D I D D L K E Y K L I F T V F H I I A M C S T F A N P L L Y G W M N S N F L S E Q R Y R K A A F R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
Y2 receptor
TM2
2x60 2.61x60 T107
2x63 2.64x63 Y110
2x64 2.65x64 T111
TM3
3x32 3.32x32 Q130
ECL2
45x51 45.51x51 T204
45x52 45.52x52 E205
TM5
5x39 5.38x39 Y219
5x40 5.39x40 S220
TM6
6x55 6.55x55 Q288
6x58 6.58x58 V291
TM7
7x30 7.31x30 Y303
7x31 7.32x31 K304
7x34 7.35x34 F307
7x38 7.39x38 H311