Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8EFO

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2022.09.041

PUBLICATION DATE

Nov. 9, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PZM21 I146 3.29x29 TM3 hydrophobic
PZM21 D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
PZM21 Y150 3.33x33 TM3 hydrophobic
PZM21 Y150 3.33x33 TM3 Van der Waals
PZM21 M153 3.36x36 TM3 Van der Waals
PZM21 K235 5.39x40 TM5 Van der Waals
PZM21 V238 5.42x43 TM5 hydrophobic
PZM21 V238 5.42x43 TM5 Van der Waals
PZM21 V302 6.55x55 TM6 hydrophobic
PZM21 V302 6.55x55 TM6 Van der Waals
PZM21 I324 7.39x38 TM7 hydrophobic
PZM21 Y328 7.43x42 TM7 Van der Waals
PZM21 Y328 7.43x42 TM7 hydrophobic

Ligands

PZM21

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x29 3.29x29 I146
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM5
5x40 5.39x40 K235
5x43 5.42x43 V238
TM6
6x55 6.55x55 V302
TM7
7x38 7.39x38 I324
7x42 7.43x42 Y328