Structure information

5-HT1A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8FYE

SPECIES

Homo sapiens

RESOLUTION

2.850

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-024-07403-2

PUBLICATION DATE

May 15, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL352186 D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL352186 V117 3.33x33 TM3 hydrophobic
CHEMBL352186 V117 3.33x33 TM3 Van der Waals
CHEMBL352186 C120 3.36x36 TM3 hydrophobic
CHEMBL352186 C120 3.36x36 TM3 Van der Waals
CHEMBL352186 T121 3.37x37 TM3 polar (hydrogen bond)
CHEMBL352186 I189 45.52x52 ECL2 hydrophobic
CHEMBL352186 I189 45.52x52 ECL2 Van der Waals
CHEMBL352186 S199 5.42x43 TM5 Van der Waals
CHEMBL352186 T200 5.43x44 TM5 Van der Waals
CHEMBL352186 A203 5.46x461 TM5 Van der Waals
CHEMBL352186 W358 6.48x48 TM6 hydrophobic
CHEMBL352186 W358 6.48x48 TM6 Van der Waals
CHEMBL352186 F361 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL352186 F361 6.51x51 TM6 Van der Waals
CHEMBL352186 F362 6.52x52 TM6 Van der Waals
CHEMBL352186 F362 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL352186 N386 7.39x38 TM7 Van der Waals
CHEMBL352186 Y390 7.43x42 TM7 Van der Waals
CHEMBL352186 Y390 7.43x42 TM7 hydrophobic

Ligands

CHEMBL352186

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Residue Diagrams

A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7
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ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM3
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
3x37 3.37x37 T121
ECL2
45x52 45.52x52 I189
TM5
5x43 5.42x43 S199
5x44 5.43x44 T200
5x461 5.46x461 A203
TM6
6x48 6.48x48 W358
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x38 7.39x38 N386
7x42 7.43x42 Y390