Structure information

5-HT1A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8FYX

SPECIES

Homo sapiens

RESOLUTION

2.620

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-024-07403-2

PUBLICATION DATE

May 15, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
buspirone V89 2.57x56 TM2 hydrophobic
buspirone M92 2.60x59 TM2 hydrophobic
buspirone A93 2.61x60 TM2 hydrophobic
buspirone Y96 2.64x63 TM2 hydrophobic
buspirone W102 23.50x50 ECL1 hydrophobic
buspirone F112 3.28x28 TM3 hydrophobic
buspirone D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
buspirone V117 3.33x33 TM3 Van der Waals
buspirone V117 3.33x33 TM3 hydrophobic
buspirone C120 3.36x36 TM3 Van der Waals
buspirone T121 3.37x37 TM3 Van der Waals
buspirone C187 45.50x50 ECL2 Van der Waals
buspirone C187 45.50x50 ECL2 polar (hydrogen bond with backbone)
buspirone I189 45.52x52 ECL2 Van der Waals
buspirone A203 5.46x461 TM5 Van der Waals
buspirone F361 6.51x51 TM6 hydrophobic
buspirone F361 6.51x51 TM6 Van der Waals
buspirone F362 6.52x52 TM6 Van der Waals
buspirone F362 6.52x52 TM6 aromatic (edge-to-face)
buspirone N386 7.39x38 TM7 Van der Waals
buspirone Y390 7.43x42 TM7 Van der Waals
buspirone Y390 7.43x42 TM7 hydrophobic

Ligands

buspirone

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Residue Diagrams

A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7
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ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM2
2x56 2.57x56 V89
2x59 2.60x59 M92
2x60 2.61x60 A93
2x63 2.64x63 Y96
ECL1
23x50 23.50x50 W102
TM3
3x28 3.28x28 F112
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
3x37 3.37x37 T121
ECL2
45x50 45.50x50 C187
45x52 45.52x52 I189
TM5
5x461 5.46x461 A203
TM6
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x38 7.39x38 N386
7x42 7.43x42 Y390