Structure information

EP4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GCP

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2216329120

PUBLICATION DATE

Jan. 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGE<sub>2</sub> P24 1.39x39 TM1 hydrophobic
PGE<sub>2</sub> T69 2.54x54 TM2 polar (hydrogen bond)
PGE<sub>2</sub> T69 2.54x54 TM2 Van der Waals
PGE<sub>2</sub> V72 2.57x57 TM2 hydrophobic
PGE<sub>2</sub> V72 2.57x57 TM2 Van der Waals
PGE<sub>2</sub> T76 2.61x61 TM2 Van der Waals
PGE<sub>2</sub> Y80 2.65x65 TM2 Van der Waals
PGE<sub>2</sub> L99 3.32x32 TM3 hydrophobic
PGE<sub>2</sub> L99 3.32x32 TM3 Van der Waals
PGE<sub>2</sub> S103 3.36x36 TM3 Van der Waals
PGE<sub>2</sub> T168 ECL2 Van der Waals
PGE<sub>2</sub> W169 ECL2 hydrophobic
PGE<sub>2</sub> W169 ECL2 Van der Waals
PGE<sub>2</sub> L312 7.36x35 TM7 hydrophobic
PGE<sub>2</sub> L312 7.36x35 TM7 Van der Waals
PGE<sub>2</sub> I315 7.39x38 TM7 Van der Waals
PGE<sub>2</sub> I315 7.39x38 TM7 hydrophobic
PGE<sub>2</sub> R316 7.40x39 TM7 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> A318 7.42x41 TM7 hydrophobic
PGE<sub>2</sub> A318 7.42x41 TM7 Van der Waals
PGE<sub>2</sub> S319 7.43x42 TM7 Van der Waals

Ligands

PGE<sub>2</sub>

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Residue Diagrams

L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7
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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x39 1.39x39 P24
TM2
2x54 2.54x54 T69
2x57 2.57x57 V72
2x61 2.61x61 T76
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
3x36 3.36x36 S103
TM7
7x35 7.36x35 L312
7x38 7.39x38 I315
7x39 7.40x39 R316
7x41 7.42x41 A318
7x42 7.43x42 S319