Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8GHV

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

D

REFERENCE

10.1038/S41467-023-37864-4

PUBLICATION DATE

May 24, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4208628 F108 N-term polar (hydrogen bond with backbone)
CHEMBL4208628 F108 N-term Van der Waals
CHEMBL4208628 F170 2.57x57 TM2 hydrophobic
CHEMBL4208628 F170 2.57x57 TM2 Van der Waals
CHEMBL4208628 S173 2.60x60 TM2 Van der Waals
CHEMBL4208628 S173 2.60x60 TM2 polar (hydrogen bond with backbone)
CHEMBL4208628 F174 2.61x61 TM2 Van der Waals
CHEMBL4208628 F177 2.64x64 TM2 hydrophobic
CHEMBL4208628 F177 2.64x64 TM2 Van der Waals
CHEMBL4208628 H178 2.65x65 TM2 polar (hydrogen bond)
CHEMBL4208628 H178 2.65x65 TM2 polar (hydrogen bond)
CHEMBL4208628 F189 3.25x25 TM3 Van der Waals
CHEMBL4208628 L193 3.29x29 TM3 Van der Waals
CHEMBL4208628 L193 3.29x29 TM3 hydrophobic
CHEMBL4208628 V196 3.32x32 TM3 Van der Waals
CHEMBL4208628 T197 3.33x33 TM3 polar (hydrogen bond)
CHEMBL4208628 F200 3.36x36 TM3 Van der Waals
CHEMBL4208628 F200 3.36x36 TM3 hydrophobic
CHEMBL4208628 I267 ECL2 polar (hydrogen bond with backbone)
CHEMBL4208628 I267 ECL2 polar (hydrogen bond)
CHEMBL4208628 F268 ECL2 Van der Waals
CHEMBL4208628 F268 ECL2 hydrophobic
CHEMBL4208628 Y275 5.39x39 TM5 Van der Waals
CHEMBL4208628 L276 5.40x40 TM5 Van der Waals
CHEMBL4208628 W279 5.43x43 TM5 Van der Waals
CHEMBL4208628 W279 5.43x43 TM5 hydrophobic
CHEMBL4208628 L359 6.51x51 TM6 Van der Waals
CHEMBL4208628 M363 6.55x55 TM6 hydrophobic
CHEMBL4208628 M363 6.55x55 TM6 Van der Waals
CHEMBL4208628 K376 7.32x31 TM7 Van der Waals
CHEMBL4208628 F379 7.35x34 TM7 Van der Waals
CHEMBL4208628 A380 7.36x35 TM7 polar (hydrogen bond)
CHEMBL4208628 S383 7.39x38 TM7 polar (hydrogen bond)
CHEMBL4208628 C386 7.42x41 TM7 Van der Waals

Ligands

CHEMBL4208628

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x60 2.60x60 S173
2x61 2.61x61 F174
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x25 3.25x25 F189
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x51 6.51x51 L359
6x55 6.55x55 M363
TM7
7x31 7.32x31 K376
7x34 7.35x34 F379
7x35 7.36x35 A380
7x38 7.39x38 S383
7x41 7.42x41 C386