Structure information

motilin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IBU

SPECIES

Homo sapiens

RESOLUTION

3.510

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADE9020

PUBLICATION DATE

April 12, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
erythromycin F33 N-term hydrophobic
erythromycin D94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
erythromycin R97 2.63x63 TM2 polar (hydrogen bond with backbone)
erythromycin R97 2.63x63 TM2 polar (charge-assisted hydrogen bond)
erythromycin S101 ECL1 polar (hydrogen bond)
erythromycin L115 3.29x29 TM3 Van der Waals
erythromycin L115 3.29x29 TM3 hydrophobic
erythromycin E119 3.33x33 TM3 polar (charge-assisted hydrogen bond)
erythromycin F173 4.60x61 TM4 Van der Waals
erythromycin E234 ECL2 polar (charge-assisted hydrogen bond)
erythromycin R236 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
erythromycin P237 45.52x52 ECL2 Van der Waals
erythromycin L245 5.36x37 TM5 Van der Waals
erythromycin L249 5.40x41 TM5 hydrophobic
erythromycin L249 5.40x41 TM5 Van der Waals
erythromycin F314 6.51x51 TM6 hydrophobic
erythromycin F314 6.51x51 TM6 Van der Waals
erythromycin R318 6.55x55 TM6 polar (charge-assisted hydrogen bond)
erythromycin Y321 6.58x58 TM6 polar (hydrogen bond)
erythromycin Q334 7.32x31 TM7 polar (hydrogen bond)
erythromycin Q334 7.32x31 TM7 polar (hydrogen bond)
erythromycin N337 7.35x34 TM7 polar (hydrogen bond with backbone)
erythromycin N337 7.35x34 TM7 polar (hydrogen bond)
erythromycin L341 7.39x38 TM7 polar (hydrogen bond with backbone)
erythromycin L341 7.39x38 TM7 Van der Waals
erythromycin F344 7.42x41 TM7 hydrophobic
erythromycin F344 7.42x41 TM7 Van der Waals
erythromycin Y345 7.43x42 TM7 Van der Waals

Ligands

erythromycin

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Residue Diagrams

V N G S V G V V F L C L C V A T V P V L 1 G S M A V S D L L I L L G L P F D L Y R 2 A T M H L L T A Y T C G E G V Y L S L R 3 V R A L I A V L W A V A L L S A G P F 4 Y L I S L C L F P L F F Y A T T V W L M V 5 L V V V L A F I I C W L P F H V G R I I 6 I P N I S A S L Y F L Q L A V I N F Y 7
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ICL1 R D M R ICL1ECL1 R P W V F ECL1ICL2 P L R A R V L V ICL2ECL2 G V E Q D P G I S V V P G L N G T A R I A S S P L A S S P P L W L S R A P P P S P P S G P E T A E A A A L F S R E C R P S P A ECL2ICL3 R G P A A ICL3ECL3 E D ECL3N-term M G S P W N G S D G P E G A R E P P W P A L P P C D E R R C S P F N-termC-term S R P R G F H R S R D T A G E V A G D T G G D T V G Y T E T S A N V K T M G C-term P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R T R R R V R A L I A V L W A V A L L S A G P F L F L V Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S S R R P L S G R E R G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K A F K R K Y R A A L L L A
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Residue Table


GPCRdb(A)
GPCRdb(A)
motilin receptor
TM2
2x60 2.60x60 D94
2x63 2.63x63 R97
TM3
3x29 3.29x29 L115
3x33 3.33x33 E119
TM4
4x61 4.60x61 F173
ECL2
45x51 45.51x51 R236
45x52 45.52x52 P237
TM5
5x37 5.36x37 L245
5x41 5.40x41 L249
TM6
6x51 6.51x51 F314
6x55 6.55x55 R318
6x58 6.58x58 Y321
TM7
7x31 7.32x31 Q334
7x34 7.35x34 N337
7x38 7.39x38 L341
7x41 7.42x41 F344
7x42 7.43x42 Y345