Structure information

D3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IRT

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-023-00808-0

PUBLICATION DATE

June 7, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
rotigotine V86 2.61x60 TM2 polar (hydrogen bond)
rotigotine L89 2.64x63 TM2 Van der Waals
rotigotine F106 3.28x28 TM3 Van der Waals
rotigotine D110 3.32x32 TM3 polar (charge-assisted hydrogen bond)
rotigotine V111 3.33x33 TM3 hydrophobic
rotigotine V111 3.33x33 TM3 Van der Waals
rotigotine C114 3.36x36 TM3 polar (hydrogen bond)
rotigotine T115 3.37x37 TM3 polar (hydrogen bond)
rotigotine S182 45.51x51 ECL2 Van der Waals
rotigotine I183 45.52x52 ECL2 Van der Waals
rotigotine S192 5.42x43 TM5 polar (hydrogen bond)
rotigotine S192 5.42x43 TM5 polar (hydrogen bond)
rotigotine S192 5.42x43 TM5 polar (hydrogen bond with backbone)
rotigotine S193 5.43x44 TM5 Van der Waals
rotigotine S196 5.46x461 TM5 polar (hydrogen bond)
rotigotine W342 6.48x48 TM6 hydrophobic
rotigotine W342 6.48x48 TM6 Van der Waals
rotigotine F345 6.51x51 TM6 Van der Waals
rotigotine F345 6.51x51 TM6 hydrophobic
rotigotine F346 6.52x52 TM6 polar (hydrogen bond)
rotigotine F346 6.52x52 TM6 aromatic (edge-to-face)
rotigotine H349 6.55x55 TM6 polar (hydrogen bond)
rotigotine H349 6.55x55 TM6 polar (hydrogen bond)
rotigotine Y365 7.35x34 TM7 Van der Waals
rotigotine T369 7.39x38 TM7 polar (hydrogen bond)
rotigotine T369 7.39x38 TM7 polar (hydrogen bond with backbone)
rotigotine G372 7.42x41 TM7 Van der Waals
rotigotine Y373 7.43x42 TM7 polar (hydrogen bond with backbone)
rotigotine Y373 7.43x42 TM7 polar (hydrogen bond)

Ligands

rotigotine

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Residue Diagrams

G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
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ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM2
2x60 2.61x60 V86
2x63 2.64x63 L89
TM3
3x28 3.28x28 F106
3x32 3.32x32 D110
3x33 3.33x33 V111
3x36 3.36x36 C114
3x37 3.37x37 T115
ECL2
45x51 45.51x51 S182
45x52 45.52x52 I183
TM5
5x43 5.42x43 S192
5x44 5.43x44 S193
5x461 5.46x461 S196
TM6
6x48 6.48x48 W342
6x51 6.51x51 F345
6x52 6.52x52 F346
6x55 6.55x55 H349
TM7
7x34 7.35x34 Y365
7x38 7.39x38 T369
7x41 7.42x41 G372
7x42 7.43x42 Y373