Structure information

GPR34

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IZ4

SPECIES

Homo sapiens

RESOLUTION

2.930

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

April 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysergide T132 3.30x30 TM3 polar (hydrogen bond with backbone)
Lysergide T132 3.30x30 TM3 Van der Waals
Lysergide T132 3.30x30 TM3 polar (hydrogen bond)
Lysergide Y135 3.33x33 TM3 hydrophobic
Lysergide Y135 3.33x33 TM3 Van der Waals
Lysergide M136 3.34x34 TM3 Van der Waals
Lysergide M136 3.34x34 TM3 hydrophobic
Lysergide L181 4.52x52 TM4 Van der Waals
Lysergide L181 4.52x52 TM4 hydrophobic
Lysergide A182 4.53x53 TM4 Van der Waals
Lysergide A182 4.53x53 TM4 hydrophobic
Lysergide M189 4.60x60 TM4 hydrophobic
Lysergide M189 4.60x60 TM4 Van der Waals
Lysergide F205 45.51x51 ECL2 Van der Waals
Lysergide R208 ECL2 polar (charge-assisted hydrogen bond)
Lysergide F219 5.39x39 TM5 hydrophobic
Lysergide N220 5.40x40 TM5 Van der Waals
Lysergide N220 5.40x40 TM5 polar (hydrogen bond)
Lysergide I222 5.42x42 TM5 hydrophobic
Lysergide L223 5.43x43 TM5 hydrophobic
Lysergide L223 5.43x43 TM5 Van der Waals
Lysergide M226 5.46x46 TM5 Van der Waals
Lysergide R286 6.55x55 TM6 polar (charge-assisted hydrogen bond)

Ligands

Lysergide

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Residue Diagrams

I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7
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ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x30 3.30x30 T132
3x33 3.33x33 Y135
3x34 3.34x34 M136
TM4
4x52 4.52x52 L181
4x53 4.53x53 A182
4x60 4.60x60 M189
ECL2
45x51 45.51x51 F205
TM5
5x39 5.39x39 F219
5x40 5.40x40 N220
5x42 5.42x42 I222
5x43 5.43x43 L223
5x46 5.46x46 M226
TM6
6x55 6.55x55 R286