Structure information

GPR174

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IZB

SPECIES

Homo sapiens

RESOLUTION

3.060

PREFERRED CHAIN

R

REFERENCE

10.1371/JOURNAL.PBIO.3002387

PUBLICATION DATE

Nov. 1, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LYSOPHOSPHATIDIC ACID Y99 3.33x33 TM3 Van der Waals
LYSOPHOSPHATIDIC ACID Y99 3.33x33 TM3 polar (hydrogen bond)
LYSOPHOSPHATIDIC ACID Y103 3.37x37 TM3 hydrophobic
LYSOPHOSPHATIDIC ACID Y103 3.37x37 TM3 Van der Waals
LYSOPHOSPHATIDIC ACID I144 4.52x52 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID I144 4.52x52 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID A148 4.56x56 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID A148 4.56x56 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID F152 4.60x60 TM4 hydrophobic
LYSOPHOSPHATIDIC ACID F152 4.60x60 TM4 Van der Waals
LYSOPHOSPHATIDIC ACID R156 ECL2 polar (charge-assisted hydrogen bond)
LYSOPHOSPHATIDIC ACID V170 45.52x52 ECL2 Van der Waals
LYSOPHOSPHATIDIC ACID M185 5.38x39 TM5 hydrophobic
LYSOPHOSPHATIDIC ACID M185 5.38x39 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID I192 5.45x46 TM5 hydrophobic
LYSOPHOSPHATIDIC ACID I192 5.45x46 TM5 Van der Waals
LYSOPHOSPHATIDIC ACID Y246 6.51x51 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID Y246 6.51x51 TM6 polar (hydrogen bond)
LYSOPHOSPHATIDIC ACID F250 6.55x55 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID F250 6.55x55 TM6 hydrophobic
LYSOPHOSPHATIDIC ACID F254 6.59x59 TM6 hydrophobic
LYSOPHOSPHATIDIC ACID F254 6.59x59 TM6 Van der Waals
LYSOPHOSPHATIDIC ACID K257 6.62x62 TM6 polar (charge-assisted hydrogen bond)
LYSOPHOSPHATIDIC ACID H274 7.35x34 TM7 Van der Waals

Ligands

LYSOPHOSPHATIDIC ACID

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Residue Diagrams

I N G I L G P V L I V T Y T V A Y I F Y 1 I N L A I A D L L Q V L S L P L R I F Y 2 C V L F Y I S A Y M N V Y K L Y F C F M 3 D L Y I S I A G W L I I C L A C V L F P 4 T C Y L V I L L P T V F G I L E G I T M M 5 L T C A G V F L I C F A P Y H F S F P L 6 V P D L C S N L S A L C L A V S H F I 7
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ICL1 K R A ICL1ECL1 D W P F ECL1ICL2 P F R F H D C ICL2ECL2 T S D D T S G N R T K C F V D L P T R N V ECL2ICL3 Q D K Y P M A Q D L ICL3ECL3 E I K ECL3N-term M P A N Y T C T R P D G D N T D N-termC-term H D S I Q L H A K S F V S N H T A S T M T P E L C C-term F R Y F I Y A V T Y T V I L V P G L I G N I L A L W V F Y G Y M K E T V I F M I N L A I A D L L Q V L S L P L R I F Y Y L N H G P G L C M F C F Y L K Y V N M Y A S I Y F L V C I S V R R F W F L M Y K Q K Y D L Y I S I A G W L I I C L A C V L F P L L R N L A Q S V V M M T I G E L I G F V T P L L I V L Y C T W K T V L S L G E K Q K A L K M I L T C A G V F L I C F A P Y H F S F P L D F L V K S N S C L A R R V I L I F H S V A L C L A S L N S C L D P V I Y Y F S T N E L S R F R R R Q D L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR174
TM3
3x33 3.33x33 Y99
3x37 3.37x37 Y103
TM4
4x52 4.52x52 I144
4x56 4.56x56 A148
4x60 4.60x60 F152
ECL2
45x52 45.52x52 V170
TM5
5x39 5.38x39 M185
5x46 5.45x46 I192
TM6
6x51 6.51x51 Y246
6x55 6.55x55 F250
6x59 6.59x59 F254
6x62 6.62x62 K257
TM7
7x34 7.35x34 H274