Structure information

GPR84

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8J18

SPECIES

Homo sapiens

RESOLUTION

2.890

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-38985-6

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(3R)-3-HYDROXYDODECANOIC ACID L100 3.32x32 TM3 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID F101 3.33x33 TM3 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID N104 3.36x36 TM3 polar (hydrogen bond)
(3R)-3-HYDROXYDODECANOIC ACID I108 3.40x40 TM3 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID I108 3.40x40 TM3 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID F152 4.57x57 TM4 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID F152 4.57x57 TM4 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID T167 ECL2 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID M183 5.43x44 TM5 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID M183 5.43x44 TM5 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID Y186 5.46x461 TM5 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID Y186 5.46x461 TM5 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID Y332 6.48x48 TM6 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID F335 6.51x51 TM6 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID F335 6.51x51 TM6 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID L336 6.52x52 TM6 hydrophobic
(3R)-3-HYDROXYDODECANOIC ACID L336 6.52x52 TM6 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID T359 7.42x41 TM7 Van der Waals
(3R)-3-HYDROXYDODECANOIC ACID T359 7.42x41 TM7 polar (hydrogen bond)

Ligands

(3R)-3-HYDROXYDODECANOIC ACID

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Residue Diagrams

V N G V T G T V A V V V G W S V A V Y R 1 A N L T L A D L L Y C L T L Q P F S V D T 2 L C L T L I S V S N S A F L L L G F V R 3 I V L A L V S T W V V G V A S F A P L 4 Y F I G V S S L G L V F Y I G M L I T T Y 5 F A V F L C F A L S Y I P F L L L N I L 6 V P N I C G N L W T L N A A L M H V V 7
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ICL1 P K L R ICL1ECL1 L H W R T ECL1ICL2 P K L F P Q V F ICL2ECL2 I L V P V V C T C S F D R I R ECL2ICL3 L R Q A S I H S N H V A R T D E A M P G R F Q E L D S R L A S G G P S E G I S S E P V S A A T T Q T L E G D S S E V G D Q I N S K R A K Q M A E K S P P E A S A K A Q P I K G A R R A ICL3ECL3 R V Q A P R ECL3N-term M W N S S D A N F S C Y H E S V L N-termC-term G P R S F H R L H C-term G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H S A K G I V L A L V S T W V V G V A S F A P L W P I Y G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K P D S S S E F G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A V V H M L A A N L T W L N G C I N P V L Y A A M N R Q Y G S F R Q A I L K R
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR84
TM3
3x32 3.32x32 L100
3x33 3.33x33 F101
3x36 3.36x36 N104
3x40 3.40x40 I108
TM4
4x57 4.57x57 F152
TM5
5x44 5.43x44 M183
5x461 5.46x461 Y186
TM6
6x48 6.48x48 Y332
6x51 6.51x51 F335
6x52 6.52x52 L336
TM7
7x41 7.42x41 T359