Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8JIQ

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2303696120

PUBLICATION DATE

Sept. 13, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Dual-agonist peptide P15 M29 N-term polar (hydrogen bond)
Dual-agonist peptide P15 L32 N-term hydrophobic
Dual-agonist peptide P15 L32 N-term Van der Waals
Dual-agonist peptide P15 W36 N-term Van der Waals
Dual-agonist peptide P15 W36 N-term aromatic (face-to-edge)
Dual-agonist peptide P15 D63 N-term Van der Waals
Dual-agonist peptide P15 K64 N-term Van der Waals
Dual-agonist peptide P15 Y65 N-term hydrophobic
Dual-agonist peptide P15 R111 N-term polar (hydrogen bond with backbone)
Dual-agonist peptide P15 R111 N-term Van der Waals
Dual-agonist peptide P15 G112 N-term Van der Waals
Dual-agonist peptide P15 G112 N-term polar (hydrogen bond with backbone)
Dual-agonist peptide P15 W115 N-term Van der Waals
Dual-agonist peptide P15 S119 N-term Van der Waals
Dual-agonist peptide P15 A135 1.33x33 TM1 Van der Waals
Dual-agonist peptide P15 Y138 1.36x36 TM1 polar (hydrogen bond)
Dual-agonist peptide P15 Y138 1.36x36 TM1 Van der Waals
Dual-agonist peptide P15 Q142 1.40x40 TM1 Van der Waals
Dual-agonist peptide P15 Y145 1.43x43 TM1 Van der Waals
Dual-agonist peptide P15 Y145 1.43x43 TM1 aromatic (face-to-edge)
Dual-agonist peptide P15 L198 2.71x71 TM2 Van der Waals
Dual-agonist peptide P15 L198 2.71x71 TM2 hydrophobic
Dual-agonist peptide P15 R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 Y202 2.75x75 TM2 polar (hydrogen bond)
Dual-agonist peptide P15 Y202 2.75x75 TM2 Van der Waals
Dual-agonist peptide P15 G207 ECL1 Van der Waals
Dual-agonist peptide P15 D208 ECL1 Van der Waals
Dual-agonist peptide P15 D209 ECL1 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 Q293 ECL2 Van der Waals
Dual-agonist peptide P15 T296 45.52x52 ECL2 polar (hydrogen bond)
Dual-agonist peptide P15 T296 45.52x52 ECL2 Van der Waals
Dual-agonist peptide P15 S297 ECL2 polar (hydrogen bond)
Dual-agonist peptide P15 S297 ECL2 Van der Waals
Dual-agonist peptide P15 N298 ECL2 polar (hydrogen bond with backbone)
Dual-agonist peptide P15 N298 ECL2 Van der Waals
Dual-agonist peptide P15 W304 5.36x37 TM5 Van der Waals
Dual-agonist peptide P15 W304 5.36x37 TM5 hydrophobic
Dual-agonist peptide P15 L307 5.39x39 TM5 Van der Waals
Dual-agonist peptide P15 R308 5.40x40 TM5 Van der Waals
Dual-agonist peptide P15 V311 5.43x43 TM5 Van der Waals
Dual-agonist peptide P15 V311 5.43x43 TM5 hydrophobic
Dual-agonist peptide P15 D385 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Dual-agonist peptide P15 L386 7.43x42 TM7 Van der Waals
Dual-agonist peptide P15 L386 7.43x42 TM7 hydrophobic

Ligands

Dual-agonist peptide P15

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x36 1.40x40 Q142
1x39 1.43x43 Y145
TM2
2x64 2.71x71 L198
2x65 2.72x72 R199
2x68 2.75x75 Y202
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x43 5.39x39 L307
5x44 5.40x40 R308
5x47 5.43x43 V311
TM7
7x37 7.42x41 D385
7x38 7.43x42 L386