Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JWY

SPECIES

Homo sapiens

RESOLUTION

2.330

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Aug. 16, 2023
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
CHEMBL5440290 Y9 1.35x35 TM1 aromatic (face-to-edge)
CHEMBL5440290 A63 2.61x60 TM2 hydrophobic
CHEMBL5440290 I66 2.64x63 TM2 hydrophobic
CHEMBL5440290 L85 3.33x33 TM3 hydrophobic
CHEMBL5440290 T88 3.36x36 TM3 polar (hydrogen bond)
CHEMBL5440290 F168 45.52x52 ECL2 hydrophobic
CHEMBL5440290 F168 45.52x52 ECL2 Van der Waals
CHEMBL5440290 E169 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL5440290 M177 5.38x40 TM5 hydrophobic
CHEMBL5440290 M177 5.38x40 TM5 Van der Waals
CHEMBL5440290 W393 6.48x48 TM6 hydrophobic
CHEMBL5440290 W393 6.48x48 TM6 Van der Waals
CHEMBL5440290 L396 6.51x51 TM6 Van der Waals
CHEMBL5440290 L396 6.51x51 TM6 hydrophobic
CHEMBL5440290 H397 6.52x52 TM6 aromatic (face-to-edge)
CHEMBL5440290 H397 6.52x52 TM6 Van der Waals
CHEMBL5440290 N400 6.55x55 TM6 polar (hydrogen bond)
CHEMBL5440290 N400 6.55x55 TM6 polar (hydrogen bond)
CHEMBL5440290 M417 7.35x34 TM7 hydrophobic
CHEMBL5440290 M417 7.35x34 TM7 Van der Waals
CHEMBL5440290 Y418 7.36x35 TM7 aromatic (face-to-edge)
CHEMBL5440290 Y418 7.36x35 TM7 Van der Waals
CHEMBL5440290 I421 7.39x38 TM7 hydrophobic
CHEMBL5440290 I421 7.39x38 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 24 of 24 entries

Ligands

CHEMBL5440290

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM1
1x35 1.35x35 Y9
TM2
2x60 2.61x60 A63
2x63 2.64x63 I66
TM3
3x33 3.33x33 L85
3x36 3.36x36 T88
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274