Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JXR

SPECIES

Homo sapiens

RESOLUTION

3.570

PREFERRED CHAIN

A

REFERENCE

10.1016/J.NEURON.2024.07.003

PUBLICATION DATE

Sept. 4, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysergide W99 3.28x28 TM3 hydrophobic
Lysergide D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Lysergide I104 3.33x33 TM3 hydrophobic
Lysergide I104 3.33x33 TM3 Van der Waals
Lysergide S107 3.36x36 TM3 Van der Waals
Lysergide S198 5.42x43 TM5 Van der Waals
Lysergide W285 6.48x48 TM6 Van der Waals
Lysergide W285 6.48x48 TM6 hydrophobic
Lysergide F288 6.51x51 TM6 Van der Waals
Lysergide F288 6.51x51 TM6 aromatic (edge-to-face)
Lysergide F289 6.52x52 TM6 hydrophobic
Lysergide F289 6.52x52 TM6 Van der Waals
Lysergide N292 6.55x55 TM6 Van der Waals
Lysergide F313 7.35x34 TM7 hydrophobic
Lysergide F313 7.35x34 TM7 Van der Waals
Lysergide V317 7.39x38 TM7 Van der Waals
Lysergide V317 7.39x38 TM7 hydrophobic
Lysergide W321 7.43x42 TM7 Van der Waals

Ligands

Lysergide

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x28 3.28x28 W99
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 S198
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x38 7.39x38 V317
7x42 7.43x42 W321