Structure information

D1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JXS

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1016/J.NEURON.2024.07.003

PUBLICATION DATE

Sept. 4, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4277264 K81 2.61x60 TM2 polar (charge-assisted hydrogen bond)
CHEMBL4277264 W99 3.28x28 TM3 Van der Waals
CHEMBL4277264 W99 3.28x28 TM3 aromatic (edge-to-face)
CHEMBL4277264 V100 3.29x29 TM3 hydrophobic
CHEMBL4277264 V100 3.29x29 TM3 Van der Waals
CHEMBL4277264 I104 3.33x33 TM3 Van der Waals
CHEMBL4277264 I104 3.33x33 TM3 hydrophobic
CHEMBL4277264 S107 3.36x36 TM3 Van der Waals
CHEMBL4277264 C186 45.50x50 ECL2 Van der Waals
CHEMBL4277264 S188 45.52x52 ECL2 Van der Waals
CHEMBL4277264 L190 ECL2 hydrophobic
CHEMBL4277264 L190 ECL2 Van der Waals
CHEMBL4277264 S198 5.42x43 TM5 Van der Waals
CHEMBL4277264 S202 5.46x461 TM5 polar (hydrogen bond)
CHEMBL4277264 F288 6.51x51 TM6 Van der Waals
CHEMBL4277264 F288 6.51x51 TM6 hydrophobic
CHEMBL4277264 F289 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL4277264 F289 6.52x52 TM6 Van der Waals
CHEMBL4277264 F313 7.35x34 TM7 hydrophobic
CHEMBL4277264 D314 7.36x35 TM7 Van der Waals

Ligands

CHEMBL4277264

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Residue Diagrams

T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7
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ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
D1 receptor
TM2
2x60 2.61x60 K81
TM3
3x28 3.28x28 W99
3x29 3.29x29 V100
3x33 3.33x33 I104
3x36 3.36x36 S107
ECL2
45x50 45.50x50 C186
45x52 45.52x52 S188
TM5
5x43 5.42x43 S198
5x461 5.46x461 S202
TM6
6x51 6.51x51 F288
6x52 6.52x52 F289
TM7
7x34 7.35x34 F313
7x35 7.36x35 D314