Structure information

H4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JXV

SPECIES

Homo sapiens

RESOLUTION

3.210

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-46840-5

PUBLICATION DATE

March 20, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
clozapine Y95 3.33x33 TM3 hydrophobic
clozapine F169 ECL2 aromatic (face-to-edge)
clozapine L175 5.39x40 TM5 hydrophobic
clozapine Y319 6.51x51 TM6 aromatic (edge-to-face)
clozapine F344 7.39x38 TM7 hydrophobic
clozapine W348 7.43x42 TM7 hydrophobic
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 6 of 6 entries

Ligands

clozapine

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Residue Diagrams

A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x33 3.33x33 Y95
TM5
5x40 5.39x40 L175
TM6
6x51 6.51x51 Y319
TM7
7x38 7.39x38 F344
7x42 7.43x42 W348