Structure information

H4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JXW

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-46840-5

PUBLICATION DATE

March 20, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL213912 Y95 3.33x33 TM3 hydrophobic
CHEMBL213912 V146 4.56x56 TM4 hydrophobic
CHEMBL213912 F169 ECL2 hydrophobic
CHEMBL213912 E182 5.46x461 TM5 polar (charge-assisted hydrogen bond)
CHEMBL213912 Y319 6.51x51 TM6 Van der Waals
CHEMBL213912 Y319 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL213912 F344 7.39x38 TM7 Van der Waals
CHEMBL213912 F344 7.39x38 TM7 hydrophobic
CHEMBL213912 Q347 7.42x41 TM7 Van der Waals
CHEMBL213912 W348 7.43x42 TM7 Van der Waals
CHEMBL213912 W348 7.43x42 TM7 hydrophobic

Ligands

CHEMBL213912

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Residue Diagrams

A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7
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ICL1 K N L R ICL1ECL1 F E W D F ECL1ICL2 A V S Y R T Q H T ICL2ECL2 D E G S E C E P G F F S ECL2ICL3 H P G L T A V S S N I C G H S F R G R L S S R R S L S A S T E V P A S F H S E R Q R R K S S L M F S S R T K M N S N T I A S K M G S F S Q S D S V A L H Q R E ICL3ECL3 S S A T G P K ECL3N-term M P D T N S T I N L N-termC-term K K Q P L P S Q H S R S V S S C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x33 3.33x33 Y95
TM4
4x56 4.56x56 V146
TM5
5x461 5.46x461 E182
TM6
6x51 6.51x51 Y319
TM7
7x38 7.39x38 F344
7x41 7.42x41 Q347
7x42 7.43x42 W348