Structure information

MRGPRX4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8KEX

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

E

REFERENCE

10.1016/J.CELL.2024.10.001

PUBLICATION DATE

Nov. 6, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DCA-3P R82 2.60x60 TM2 polar (charge-assisted hydrogen bond)
DCA-3P R95 3.25x25 TM3 polar (hydrogen bond with backbone)
DCA-3P R95 3.25x25 TM3 Van der Waals
DCA-3P K96 3.26x26 TM3 Van der Waals
DCA-3P V99 3.29x29 TM3 hydrophobic
DCA-3P V99 3.29x29 TM3 Van der Waals
DCA-3P T103 3.33x33 TM3 Van der Waals
DCA-3P F107 3.37x37 TM3 hydrophobic
DCA-3P F107 3.37x37 TM3 Van der Waals
DCA-3P F232 6.51x51 TM6 Van der Waals
DCA-3P G233 6.52x52 TM6 Van der Waals
DCA-3P G236 6.55x55 TM6 Van der Waals
DCA-3P A237 6.56x56 TM6 polar (hydrogen bond with backbone)
DCA-3P A237 6.56x56 TM6 Van der Waals
DCA-3P I239 ECL3 Van der Waals
DCA-3P I239 ECL3 hydrophobic
DCA-3P Y240 ECL3 Van der Waals
DCA-3P L246 ECL3 hydrophobic
DCA-3P L246 ECL3 Van der Waals
DCA-3P Y254 7.35x34 TM7 Van der Waals
DCA-3P Y254 7.35x34 TM7 hydrophobic

Ligands

DCA-3P

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Residue Diagrams

A N G T L G V L S I I C T L V T F S L T 1 L N L A A A D F L F L S F Q I I R L P L 2 A S L M S L G T F Y P F T M V S V L I K 3 S A V V C V L L W G L S L L F S M L E W 4 S S V C L V V C L F I L W A V P I F D S 5 L L T V L V F L L C G L P F G I L G A L 6 I P N A S S N L S S L S M C V L Y V H 7
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ICL1 R R ICL1ECL1 I N I ECL1ICL2 P I W Y R C R R P T ICL2ECL2 D F L F S G A ECL2ICL3 G S R K M ICL3ECL3 I Y R M H L N L E ECL3N-term M D P T V P V F G T K L T P I N G R E E T P C Y N N-termC-term Q R Q N R Q N L K L V L Q R A L Q D K P E V D K G E G Q L P E E S L E L S G S R L G P C-term Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W H L S A V V C V L L W G L S L L F S M L E W R F C D S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX4
TM2
2x60 2.60x60 R82
TM3
3x25 3.25x25 R95
3x26 3.26x26 K96
3x29 3.29x29 V99
3x33 3.33x33 T103
3x37 3.37x37 F107
TM6
6x51 6.51x51 F232
6x52 6.52x52 G233
6x55 6.55x55 G236
6x56 6.56x56 A237
TM7
7x34 7.35x34 Y254