Structure information

H2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8POK

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-024-46096-Z

PUBLICATION DATE

March 6, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
histamine D104 3.32x32 TM3 polar (hydrogen bond with backbone)
histamine D104 3.32x32 TM3 polar (charge-assisted hydrogen bond)
histamine V105 3.33x33 TM3 Van der Waals

Ligands

histamine

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Residue Diagrams

V N G A V T I L I L V A L V V T I T I K 1 V S L A I T D L L L G L L V L P F S A I Y 2 M F L N L I S A T C L M V D L S T Y I N 3 V A I S L V L I W V I S I T L S F L S I 4 Y T I C M I L L P L Y F T V L G D V L G Y 5 A A V M G A F I I C W F P Y F T A F V Y 6 I P N L A S N A Y G L W L V I A E L V 7
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ICL1 R R L R ICL1ECL1 K W S F ECL1ICL2 P L R Y P V L V ICL2ECL2 W N S R N E T S K G N H T T S K C K V Q V ECL2ICL3 H I S ICL3ECL3 G D D A I ECL3N-term M A P N G T A S S N-termC-term C R L A N R N S H K T S L R S N A S Q L S R T Q S R E P R Q Q E E K P L K L Q V W S G T E V T A P Q G A T D R C-term F C L D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D T P V R V A I S L V L I W V I S I T L S F L S I H L G N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D Y Q Q F R T G L F C
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Residue Table


GPCRdb(A)
GPCRdb(A)
H2 receptor
TM3
3x32 3.32x32 D98
3x33 3.33x33 V99