Structure information

μ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8QOT

SPECIES

Mus musculus

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1101/2023.12.06.570395

PUBLICATION DATE

Dec. 27, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Nanobody-E Y148 3.33x33 TM3 polar (hydrogen bond)
Nanobody-E Y148 3.33x33 TM3 Van der Waals
Nanobody-E M151 3.36x36 TM3 Van der Waals
Nanobody-E M151 3.36x36 TM3 hydrophobic
Nanobody-E K209 ECL2 polar (charge-assisted hydrogen bond)
Nanobody-E R211 ECL2 polar (charge-assisted hydrogen bond)
Nanobody-E Q212 ECL2 Van der Waals
Nanobody-E T218 45.51x51 ECL2 Van der Waals
Nanobody-E L219 45.52x52 ECL2 Van der Waals
Nanobody-E L219 45.52x52 ECL2 hydrophobic
Nanobody-E E229 5.35x36 TM5 polar (charge-assisted hydrogen bond)
Nanobody-E K233 5.39x40 TM5 polar (charge-assisted hydrogen bond)
Nanobody-E W293 6.48x48 TM6 hydrophobic
Nanobody-E W293 6.48x48 TM6 Van der Waals
Nanobody-E H297 6.52x52 TM6 aromatic (face-to-edge)
Nanobody-E H297 6.52x52 TM6 Van der Waals
Nanobody-E H297 6.52x52 TM6 polar (hydrogen bond)
Nanobody-E V300 6.55x55 TM6 hydrophobic
Nanobody-E V300 6.55x55 TM6 Van der Waals
Nanobody-E K303 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Nanobody-E E310 ECL3 polar (hydrogen bond with backbone)
Nanobody-E E310 ECL3 polar (charge-assisted hydrogen bond)
Nanobody-E W318 7.35x34 TM7 polar (hydrogen bond)
Nanobody-E I322 7.39x38 TM7 Van der Waals

Ligands

Nanobody-E

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Residue Diagrams

F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x51 45.51x51 T218
45x52 45.52x52 L219
TM5
5x36 5.35x36 E229
5x40 5.39x40 K233
TM6
6x48 6.48x48 W293
6x52 6.52x52 H297
6x55 6.55x55 V300
6x58 6.58x58 K303
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322