Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8S4D

SPECIES

Homo sapiens

RESOLUTION

2.580

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 4, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
CMF-019 F78 2.53x53 TM2 hydrophobic
CMF-019 W85 2.60x60 TM2 hydrophobic
CMF-019 I109 3.32x32 TM3 hydrophobic
CMF-019 F110 3.33x33 TM3 hydrophobic
CMF-019 Y185 ECL2 Van der Waals
CMF-019 Y185 ECL2 polar (hydrogen bond)
CMF-019 W261 6.48x48 TM6 Van der Waals
CMF-019 Y264 6.51x51 TM6 polar (hydrogen bond)
CMF-019 Y264 6.51x51 TM6 Van der Waals
CMF-019 Y264 6.51x51 TM6 aromatic (edge-to-face)
CMF-019 K268 6.55x55 TM6 Van der Waals
CMF-019 Y271 6.58x58 TM6 hydrophobic
CMF-019 Y271 6.58x58 TM6 Van der Waals
CMF-019 F291 7.35x34 TM7 hydrophobic
CMF-019 F291 7.35x34 TM7 Van der Waals
CMF-019 T295 7.39x38 TM7 Van der Waals
CMF-019 Y299 7.43x42 TM7 aromatic (face-to-edge)
CMF-019 Y299 7.43x42 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 18 of 18 entries

Ligands

CMF-019

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x53 2.53x53 F78
2x60 2.60x60 W85
TM3
3x32 3.32x32 I109
3x33 3.33x33 F110
TM6
6x48 6.48x48 W261
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 Y299