Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8T3O

SPECIES

Homo sapiens

RESOLUTION

3.060

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADJ2384

PUBLICATION DATE

Jan. 17, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TUG-891 F27 N-term hydrophobic
TUG-891 F88 2.53x53 TM2 hydrophobic
TUG-891 F115 3.29x29 TM3 aromatic (edge-to-face)
TUG-891 M118 3.32x32 TM3 polar (hydrogen bond)
TUG-891 T119 3.33x33 TM3 Van der Waals
TUG-891 T119 3.33x33 TM3 polar (hydrogen bond)
TUG-891 G122 3.36x36 TM3 Van der Waals
TUG-891 S123 3.37x37 TM3 Van der Waals
TUG-891 I126 3.40x40 TM3 Van der Waals
TUG-891 I126 3.40x40 TM3 hydrophobic
TUG-891 L173 4.60x61 TM4 Van der Waals
TUG-891 L173 4.60x61 TM4 hydrophobic
TUG-891 L196 45.52x52 ECL2 hydrophobic
TUG-891 L196 45.52x52 ECL2 Van der Waals
TUG-891 E204 5.35x36 TM5 polar (charge-assisted hydrogen bond)
TUG-891 D208 5.39x40 TM5 polar (charge-assisted hydrogen bond)
TUG-891 F211 5.42x43 TM5 hydrophobic
TUG-891 F211 5.42x43 TM5 Van der Waals
TUG-891 N215 5.46x461 TM5 Van der Waals
TUG-891 W277 6.48x48 TM6 aromatic (edge-to-face)
TUG-891 W277 6.48x48 TM6 Van der Waals
TUG-891 I280 6.51x51 TM6 hydrophobic
TUG-891 I280 6.51x51 TM6 Van der Waals
TUG-891 I281 6.52x52 TM6 hydrophobic
TUG-891 I284 6.55x55 TM6 polar (hydrogen bond with backbone)
TUG-891 I284 6.55x55 TM6 Van der Waals
TUG-891 I287 6.58x58 TM6 hydrophobic
TUG-891 I287 6.58x58 TM6 Van der Waals
TUG-891 L288 6.59x59 TM6 polar (hydrogen bond with backbone)
TUG-891 L288 6.59x59 TM6 Van der Waals
TUG-891 F303 7.35x34 TM7 hydrophobic
TUG-891 V307 7.39x38 TM7 Van der Waals
TUG-891 T310 7.42x41 TM7 Van der Waals

Ligands

TUG-891

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM2
2x53 2.53x53 F88
TM3
3x29 3.29x29 F115
3x32 3.32x32 M118
3x33 3.33x33 T119
3x36 3.36x36 G122
3x37 3.37x37 S123
3x40 3.40x40 I126
TM4
4x61 4.60x61 L173
ECL2
45x52 45.52x52 L196
TM5
5x36 5.35x36 E204
5x40 5.39x40 D208
5x43 5.42x43 F211
5x461 5.46x461 N215
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x52 6.52x52 I281
6x55 6.55x55 I284
6x58 6.58x58 I287
6x59 6.59x59 L288
TM7
7x34 7.35x34 F303
7x38 7.39x38 V307
7x41 7.42x41 T310