Structure information

FFA4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8T3Q

SPECIES

Homo sapiens

RESOLUTION

3.140

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADJ2384

PUBLICATION DATE

Jan. 24, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid R22 N-term polar (charge-assisted hydrogen bond)
docosahexaenoic acid M118 3.32x32 TM3 hydrophobic
docosahexaenoic acid M118 3.32x32 TM3 Van der Waals
docosahexaenoic acid T119 3.33x33 TM3 Van der Waals
docosahexaenoic acid G122 3.36x36 TM3 Van der Waals
docosahexaenoic acid S123 3.37x37 TM3 Van der Waals
docosahexaenoic acid I126 3.40x40 TM3 Van der Waals
docosahexaenoic acid L173 4.60x61 TM4 Van der Waals
docosahexaenoic acid L173 4.60x61 TM4 hydrophobic
docosahexaenoic acid L196 45.52x52 ECL2 hydrophobic
docosahexaenoic acid E204 5.35x36 TM5 Van der Waals
docosahexaenoic acid D208 5.39x40 TM5 Van der Waals
docosahexaenoic acid F211 5.42x43 TM5 hydrophobic
docosahexaenoic acid F211 5.42x43 TM5 Van der Waals
docosahexaenoic acid W277 6.48x48 TM6 hydrophobic
docosahexaenoic acid W277 6.48x48 TM6 Van der Waals
docosahexaenoic acid I280 6.51x51 TM6 hydrophobic
docosahexaenoic acid I280 6.51x51 TM6 Van der Waals
docosahexaenoic acid I284 6.55x55 TM6 Van der Waals
docosahexaenoic acid I284 6.55x55 TM6 hydrophobic
docosahexaenoic acid I287 6.58x58 TM6 hydrophobic
docosahexaenoic acid I287 6.58x58 TM6 Van der Waals
docosahexaenoic acid N291 6.62x62 TM6 Van der Waals
docosahexaenoic acid N291 6.62x62 TM6 polar (hydrogen bond)
docosahexaenoic acid F303 7.35x34 TM7 hydrophobic

Ligands

docosahexaenoic acid

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Residue Diagrams

V N G L L S V A F I L V L V T T E V A A 1 L N L F C A D L L F I S A I P L V L A V 2 A A L T L I T V S G S L T M V Y F L L H 3 R A V L L A L I W G Y S A V A A L P L 4 Y S I V I V L G P V L F N L T V F S V D W 5 L F L L M V S F I F M W S P I I I T I L L 6 I P N L A S N A F T F A V V W F F L S 7
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ICL1 R R R G A T ICL1ECL1 E A W L L ECL1ICL2 L Q R G V R G P ICL2ECL2 R V V P Q R L P G A D Q E I S I C T L I W P ECL2ICL3 A Y ICL3ECL3 D L V I ECL3N-term M S P E C A R A A G D A P L R S L E Q A N R T R F P F F S D V K G D N-termC-term P E K G A I L T D T S V K R N D L S I I S G C-term H R L V L A A V E T T V L V L I F A V S L L G N V C A L V L V A R R A C L V L N L F C A D L L F I S A I P L V L A V R W T G P V A C H L L F Y V M T L S G S V T I L T L A A V S L E R M V C I V H G R R A R A V L L A L I W G Y S A V A A L P L C V F F T I P G E I S W D V S F V T L N F L V P G L V I V I S Y S K I L Q I T K A S R K R L T V S L S E S H Q I R V S Q Q D F R L F R T L F L L M V S F F I M W S P I I I T I L L I L I Q N F K Q W P S L F F W V V A F T F A N S A L N P I L Y N M T L C R K I F F N E W K C C F W
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA4 receptor
TM3
3x32 3.32x32 M118
3x33 3.33x33 T119
3x36 3.36x36 G122
3x37 3.37x37 S123
3x40 3.40x40 I126
TM4
4x61 4.60x61 L173
ECL2
45x52 45.52x52 L196
TM5
5x36 5.35x36 E204
5x40 5.39x40 D208
5x43 5.42x43 F211
TM6
6x48 6.48x48 W277
6x51 6.51x51 I280
6x55 6.55x55 I284
6x58 6.58x58 I287
6x62 6.62x62 N291
TM7
7x34 7.35x34 F303