Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8U02

SPECIES

Homo sapiens

RESOLUTION

3.280

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-50964-Z

PUBLICATION DATE

Aug. 21, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
dopamine D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dopamine V115 3.33x33 TM3 hydrophobic
dopamine V115 3.33x33 TM3 Van der Waals
dopamine C118 3.36x36 TM3 Van der Waals
dopamine S193 5.42x43 TM5 polar (hydrogen bond)
dopamine S197 5.46x461 TM5 polar (hydrogen bond)
dopamine W386 6.48x48 TM6 hydrophobic
dopamine W386 6.48x48 TM6 Van der Waals
dopamine F389 6.51x51 TM6 Van der Waals
dopamine F389 6.51x51 TM6 aromatic (edge-to-face)
dopamine F390 6.52x52 TM6 hydrophobic
dopamine F390 6.52x52 TM6 Van der Waals
dopamine H393 6.55x55 TM6 polar (hydrogen bond)
dopamine H393 6.55x55 TM6 Van der Waals
dopamine Y416 7.43x42 TM7 polar (hydrogen bond)

Ligands

dopamine

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 V115
3x36 3.36x36 C118
TM5
5x43 5.42x43 S193
5x461 5.46x461 S197
TM6
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
6x55 6.55x55 H393
TM7
7x42 7.43x42 Y416