Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8UGW

SPECIES

Homo sapiens

RESOLUTION

3.900

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 18, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
CGS 21680 S67 2.65x64 TM2 Van der Waals
CGS 21680 L85 3.33x33 TM3 Van der Waals
CGS 21680 T88 3.36x36 TM3 polar (hydrogen bond)
CGS 21680 Q89 3.37x37 TM3 Van der Waals
CGS 21680 L167 45.51x51 ECL2 Van der Waals
CGS 21680 L167 45.51x51 ECL2 hydrophobic
CGS 21680 F168 45.52x52 ECL2 Van der Waals
CGS 21680 F168 45.52x52 ECL2 aromatic (face-to-face)
CGS 21680 E169 ECL2 polar (charge-assisted hydrogen bond)
CGS 21680 M177 5.38x40 TM5 Van der Waals
CGS 21680 N181 5.42x43 TM5 Van der Waals
CGS 21680 W246 6.48x48 TM6 Van der Waals
CGS 21680 W246 6.48x48 TM6 hydrophobic
CGS 21680 L249 6.51x51 TM6 Van der Waals
CGS 21680 L249 6.51x51 TM6 hydrophobic
CGS 21680 N253 6.55x55 TM6 polar (hydrogen bond)
CGS 21680 N253 6.55x55 TM6 polar (hydrogen bond)
CGS 21680 H264 ECL3 Van der Waals
CGS 21680 M270 7.35x34 TM7 Van der Waals
CGS 21680 M270 7.35x34 TM7 hydrophobic
CGS 21680 I274 7.39x38 TM7 Van der Waals
CGS 21680 H278 7.43x42 TM7 Van der Waals
CGS 21680 H278 7.43x42 TM7 polar (hydrogen bond)
CGS 21680 R1115 polar (charge-assisted hydrogen bond)
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 24 of 24 entries

Ligands

CGS 21680

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM2
2x64 2.65x64 S67
TM3
3x33 3.33x33 L85
3x36 3.36x36 T88
3x37 3.37x37 Q89
ECL2
45x51 45.51x51 L167
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
5x43 5.42x43 N181
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
7x42 7.43x42 H278