Structure information

MCH1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WSS

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00679-8

PUBLICATION DATE

June 19, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
pro-MCH D192 3.32x32 TM3 polar (charge-assisted hydrogen bond)
pro-MCH Q196 3.36x36 TM3 polar (hydrogen bond)
pro-MCH I254 ECL2 Van der Waals
pro-MCH I254 ECL2 hydrophobic
pro-MCH F256 ECL2 Van der Waals
pro-MCH F256 ECL2 hydrophobic
pro-MCH C263 45.50x50 ECL2 Van der Waals
pro-MCH C263 45.50x50 ECL2 polar (hydrogen bond with backbone)
pro-MCH G264 45.51x51 ECL2 Van der Waals
pro-MCH I265 45.52x52 ECL2 Van der Waals
pro-MCH I265 45.52x52 ECL2 hydrophobic
pro-MCH R266 ECL2 Van der Waals
pro-MCH D271 ECL2 Van der Waals
pro-MCH L274 5.35x36 TM5 Van der Waals
pro-MCH L274 5.35x36 TM5 hydrophobic
pro-MCH Y341 6.51x51 TM6 Van der Waals
pro-MCH Q345 6.55x55 TM6 Van der Waals
pro-MCH Q348 6.58x58 TM6 polar (hydrogen bond)
pro-MCH Q348 6.58x58 TM6 polar (hydrogen bond)
pro-MCH S352 ECL3 Van der Waals
pro-MCH R353 ECL3 Van der Waals
pro-MCH P354 ECL3 Van der Waals
pro-MCH V359 7.32x31 TM7 Van der Waals
pro-MCH V359 7.32x31 TM7 hydrophobic
pro-MCH Y362 7.35x34 TM7 polar (hydrogen bond)
pro-MCH I366 7.39x38 TM7 Van der Waals
pro-MCH I366 7.39x38 TM7 hydrophobic

Ligands

pro-MCH

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Residue Diagrams

S N G I I G L L C I T G F V S P M I I N 1 I N L S V V D L L F L L G M P F M I H Q 2 A T L I Y T S T F Q S N A D M A T I L T 3 A T L V I C L L W A L S F I S I T P V 4 Y A A T I V V F P L A F A L F F Q Y L T F 5 I A I C L V F F V C W A P Y Y V L Q L T 6 F P N L C S N A Y G L S I A A N Y L Y 7
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ICL1 K L H W C N ICL1ECL1 N G V W H F ECL1ICL2 P I S S T K F R ICL2ECL2 R L I P F P G G A V G C G I R L P N ECL2ICL3 T S S V A P A S ICL3ECL3 S R P T ECL3N-term M S V G A M K K G V G R A V G L G G G S G C Q A T E E D P L P N C G A C A P G Q G G R R W R L P Q P A W V E G S S A R L W E Q A T G T G W M D L E A S L L P T G P N A S N T S D G P D N L T S A G S P P R T G S I N-termC-term P A A Q G Q L R A V S N A Q T A D E E R T E S K G T C-term S Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H K P S V A T L V I C L L W A L S F I S I T P V W L Y A P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T L V L F R K R S V K
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Residue Table


GPCRdb(A)
GPCRdb(A)
MCH1 receptor
TM3
3x32 3.32x32 D192
3x36 3.36x36 Q196
ECL2
45x50 45.50x50 C263
45x51 45.51x51 G264
45x52 45.52x52 I265
TM5
5x36 5.35x36 L274
TM6
6x51 6.51x51 Y341
6x55 6.55x55 Q345
6x58 6.58x58 Q348
TM7
7x31 7.32x31 V359
7x34 7.35x34 Y362
7x38 7.39x38 I366