Structure information

MCH1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WWM

SPECIES

Homo sapiens

RESOLUTION

2.810

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00754-0

PUBLICATION DATE

Nov. 13, 2024
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Melanin-concentrating hormone Q171 2.63x63 TM2 polar (hydrogen bond with backbone)
Melanin-concentrating hormone Q171 2.63x63 TM2 Van der Waals
Melanin-concentrating hormone L172 2.64x64 TM2 hydrophobic
Melanin-concentrating hormone L172 2.64x64 TM2 Van der Waals
Melanin-concentrating hormone G174 ECL1 Van der Waals
Melanin-concentrating hormone G174 ECL1 polar (hydrogen bond with backbone)
Melanin-concentrating hormone N175 ECL1 Van der Waals
Melanin-concentrating hormone G176 ECL1 Van der Waals
Melanin-concentrating hormone D192 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Melanin-concentrating hormone Q196 3.36x36 TM3 polar (hydrogen bond)
Melanin-concentrating hormone I254 ECL2 Van der Waals
Melanin-concentrating hormone I254 ECL2 hydrophobic
Melanin-concentrating hormone F256 ECL2 aromatic (edge-to-face)
Melanin-concentrating hormone F256 ECL2 Van der Waals
Melanin-concentrating hormone C263 45.50x50 ECL2 Van der Waals
Melanin-concentrating hormone G264 45.51x51 ECL2 Van der Waals
Melanin-concentrating hormone I265 45.52x52 ECL2 Van der Waals
Melanin-concentrating hormone I265 45.52x52 ECL2 polar (hydrogen bond with backbone)
Melanin-concentrating hormone R266 ECL2 Van der Waals
Melanin-concentrating hormone L274 5.35x36 TM5 hydrophobic
Melanin-concentrating hormone L274 5.35x36 TM5 Van der Waals
Melanin-concentrating hormone F277 5.38x39 TM5 hydrophobic
Melanin-concentrating hormone F277 5.38x39 TM5 Van der Waals
Melanin-concentrating hormone Y341 6.51x51 TM6 polar (hydrogen bond)
Melanin-concentrating hormone Y341 6.51x51 TM6 polar (hydrogen bond)
Melanin-concentrating hormone Q345 6.55x55 TM6 Van der Waals
Melanin-concentrating hormone Q348 6.58x58 TM6 polar (hydrogen bond)
Melanin-concentrating hormone Q348 6.58x58 TM6 Van der Waals
Melanin-concentrating hormone S352 ECL3 Van der Waals
Melanin-concentrating hormone P354 ECL3 hydrophobic
Melanin-concentrating hormone P354 ECL3 Van der Waals
Melanin-concentrating hormone L356 7.29x28 TM7 hydrophobic
Melanin-concentrating hormone L356 7.29x28 TM7 Van der Waals
Melanin-concentrating hormone V359 7.32x31 TM7 Van der Waals
Melanin-concentrating hormone V359 7.32x31 TM7 hydrophobic
Melanin-concentrating hormone Y360 7.33x32 TM7 Van der Waals
Melanin-concentrating hormone Y362 7.35x34 TM7 polar (hydrogen bond)
Melanin-concentrating hormone Y362 7.35x34 TM7 polar (hydrogen bond)
Melanin-concentrating hormone I366 7.39x38 TM7 hydrophobic
Melanin-concentrating hormone I366 7.39x38 TM7 Van der Waals
Melanin-concentrating hormone Y370 7.43x42 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 41 of 41 entries

Ligands

Melanin-concentrating hormone

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Residue Diagrams

S N G I I G L L C I T G F V S P M I I N 1 I N L S V V D L L F L L G M P F M I H Q 2 A T L I Y T S T F Q S N A D M A T I L T 3 A T L V I C L L W A L S F I S I T P V 4 Y A A T I V V F P L A F A L F F Q Y L T F 5 I A I C L V F F V C W A P Y Y V L Q L T 6 F P N L C S N A Y G L S I A A N Y L Y 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term S Y I N I I M P S V F G T I C L L G I I G N S T V I F A V V K K S N V P D I F I I N L S V V D L L F L L G M P F M I H Q L M G G E T M C T L I T A M D A N S Q F T S T Y I L T A M A I D R Y L A T V H K P S V A T L V I C L L W A L S F I S I T P V W L Y A P D T D L Y W F T L Y Q F F L A F A L P F V V I T A A Y V R I L Q R M Q R S I R L R T K R V T R T A I A I C L V F F V C W A P Y Y V L Q L T Q L S I L T F V Y L Y N A A I S L G Y A N S C L N P F V Y I V L C E T L V L F R K R S V K
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Residue Table


GPCRdb(A)
GPCRdb(A)
MCH1 receptor
TM2
2x63 2.63x63 Q171
2x64 2.64x64 L172
TM3
3x32 3.32x32 D192
3x36 3.36x36 Q196
ECL2
45x50 45.50x50 C263
45x51 45.51x51 G264
45x52 45.52x52 I265
TM5
5x36 5.35x36 L274
5x39 5.38x39 F277
TM6
6x51 6.51x51 Y341
6x55 6.55x55 Q345
6x58 6.58x58 Q348
TM7
7x28 7.29x28 L356
7x31 7.32x31 V359
7x32 7.33x32 Y360
7x34 7.35x34 Y362
7x38 7.39x38 I366
7x42 7.43x42 Y370