Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X3L

SPECIES

Homo sapiens

RESOLUTION

3.130

PREFERRED CHAIN

R

REFERENCE

10.1073/PNAS.2401091121

PUBLICATION DATE

Nov. 20, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL5422946 F87 2.57x57 TM2 hydrophobic
CHEMBL5422946 I110 3.29x29 TM3 hydrophobic
CHEMBL5422946 V113 3.32x32 TM3 hydrophobic
CHEMBL5422946 F117 3.36x36 TM3 hydrophobic
CHEMBL5422946 F183 ECL2 hydrophobic
CHEMBL5422946 W194 5.43x43 TM5 hydrophobic
CHEMBL5422946 S285 7.39x38 TM7 polar (hydrogen bond)
CHEMBL5422946 S285 7.39x38 TM7 Van der Waals

Ligands

CHEMBL5422946

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
TM3
3x29 3.29x29 I110
3x32 3.32x32 V113
3x36 3.36x36 F117
TM5
5x43 5.43x43 W194
TM7
7x38 7.39x38 S285