Structure information

H1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X63

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

B

REFERENCE

10.1038/S41467-023-44477-4

PUBLICATION DATE

Jan. 17, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
mepyramine Y108 3.33x33 TM3 hydrophobic
mepyramine I115 3.40x40 TM3 hydrophobic
mepyramine W158 4.56x57 TM4 aromatic (edge-to-face)
mepyramine A195 5.43x44 TM5 hydrophobic
mepyramine W428 6.48x48 TM6 aromatic (face-to-edge)
mepyramine Y431 6.51x51 TM6 polar (hydrogen bond)
mepyramine F432 6.52x52 TM6 aromatic (edge-to-face)
mepyramine F432 6.52x52 TM6 Van der Waals
mepyramine F435 6.55x55 TM6 hydrophobic
mepyramine F435 6.55x55 TM6 Van der Waals
mepyramine I454 7.39x38 TM7 Van der Waals
mepyramine I454 7.39x38 TM7 hydrophobic
mepyramine Y458 7.43x42 TM7 Van der Waals

Ligands

mepyramine

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Residue Diagrams

L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7
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ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
H1 receptor
TM3
3x33 3.33x33 Y108
3x40 3.40x40 I115
TM4
4x57 4.56x57 W158
TM5
5x44 5.43x44 A195
TM6
6x48 6.48x48 W428
6x51 6.51x51 Y431
6x52 6.52x52 F432
6x55 6.55x55 F435
TM7
7x38 7.39x38 I454
7x42 7.43x42 Y458