Structure information

SST3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XIQ

SPECIES

Homo sapiens

RESOLUTION

2.710

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

July 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NIT-FC0-NLE-A1D5B F99 2.59x59 TM2 polar (hydrogen bond with backbone)
NIT-FC0-NLE-A1D5B F99 2.59x59 TM2 Van der Waals
NIT-FC0-NLE-A1D5B L100 2.60x60 TM2 Van der Waals
NIT-FC0-NLE-A1D5B L100 2.60x60 TM2 polar (hydrogen bond with backbone)
NIT-FC0-NLE-A1D5B Q103 2.63x63 TM2 polar (hydrogen bond)
NIT-FC0-NLE-A1D5B Q103 2.63x63 TM2 polar (hydrogen bond)
NIT-FC0-NLE-A1D5B V119 3.28x28 TM3 hydrophobic
NIT-FC0-NLE-A1D5B V119 3.28x28 TM3 Van der Waals
NIT-FC0-NLE-A1D5B M120 3.29x29 TM3 polar (hydrogen bond)
NIT-FC0-NLE-A1D5B M120 3.29x29 TM3 polar (hydrogen bond with backbone)
NIT-FC0-NLE-A1D5B D123 3.32x32 TM3 polar (charge-assisted hydrogen bond)
NIT-FC0-NLE-A1D5B G124 3.33x33 TM3 Van der Waals
NIT-FC0-NLE-A1D5B G124 3.33x33 TM3 polar (hydrogen bond with backbone)
NIT-FC0-NLE-A1D5B Q127 3.36x36 TM3 polar (hydrogen bond)
NIT-FC0-NLE-A1D5B Q127 3.36x36 TM3 polar (hydrogen bond)
NIT-FC0-NLE-A1D5B F128 3.37x37 TM3 hydrophobic
NIT-FC0-NLE-A1D5B F128 3.37x37 TM3 Van der Waals
NIT-FC0-NLE-A1D5B V175 4.57x57 TM4 Van der Waals
NIT-FC0-NLE-A1D5B V178 4.60x61 TM4 Van der Waals
NIT-FC0-NLE-A1D5B V179 4.61x62 TM4 Van der Waals
NIT-FC0-NLE-A1D5B C191 45.50x50 ECL2 Van der Waals
NIT-FC0-NLE-A1D5B M193 45.52x52 ECL2 polar (hydrogen bond)
NIT-FC0-NLE-A1D5B W195 ECL2 Van der Waals
NIT-FC0-NLE-A1D5B W195 ECL2 hydrophobic
NIT-FC0-NLE-A1D5B F206 5.38x39 TM5 hydrophobic
NIT-FC0-NLE-A1D5B F206 5.38x39 TM5 Van der Waals
NIT-FC0-NLE-A1D5B I207 5.39x40 TM5 Van der Waals
NIT-FC0-NLE-A1D5B F273 6.51x51 TM6 hydrophobic
NIT-FC0-NLE-A1D5B F273 6.51x51 TM6 Van der Waals
NIT-FC0-NLE-A1D5B N277 6.55x55 TM6 Van der Waals
NIT-FC0-NLE-A1D5B Y295 7.35x34 TM7 Van der Waals
NIT-FC0-NLE-A1D5B V299 7.39x38 TM7 hydrophobic
NIT-FC0-NLE-A1D5B V299 7.39x38 TM7 Van der Waals
NIT-FC0-NLE-A1D5B Y303 7.43x42 TM7 polar (hydrogen bond)

Ligands

NIT-FC0-NLE-A1D5B

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Residue Diagrams

S N G L L G V V C V V L Y V L P I L V G 1 L N L A L A D E L F M L G L P F L A A Q 2 V T L C F I S T F Q N I G D V A M V L R 3 A R T V S A A V W V A S A V V V L P V 4 Y C L C I V L L P G F F G L A A T Y I I F 5 V A V V A L F V L C W M P F Y V L N I V 6 I P N A C S N A Y P L A V V L F Y L G 7
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ICL1 T A S P ICL1ECL1 Y W P F ECL1ICL2 P T R S A R W R ICL2ECL2 G V P R G M S T C H M Q W P E ECL2ICL3 W A P S C Q R ICL3ECL3 P L P E ECL3N-term M D M L H P S S V S T T S E P E N A S S A W P P D A T L G N V S A G P S P A G L A N-termC-term R P S R R V R S Q E P T V G P P E K T E E E D E E E E D G E E S R E G G K G K E M N G R V S Q I T Q P G T S G Q E R P P S R V A S K E Q Q L L P Q E A S T G E K S S T M R I S Y L C-term V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H T A P V A R T V S A A V W V A S A V V V L P V V V F S P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F R R F K Q G V L L
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST3 receptor
TM2
2x59 2.59x59 F99
2x60 2.60x60 L100
2x63 2.63x63 Q103
TM3
3x28 3.28x28 V119
3x29 3.29x29 M120
3x32 3.32x32 D123
3x33 3.33x33 G124
3x36 3.36x36 Q127
3x37 3.37x37 F128
TM4
4x57 4.57x57 V175
4x61 4.60x61 V178
4x62 4.61x62 V179
ECL2
45x50 45.50x50 C191
45x52 45.52x52 M193
TM5
5x39 5.38x39 F206
5x40 5.39x40 I207
TM6
6x51 6.51x51 F273
6x55 6.55x55 N277
TM7
7x34 7.35x34 Y295
7x38 7.39x38 V299
7x42 7.43x42 Y303