Structure information

TAS2R14

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

8XQL

SPECIES

Homo sapiens

RESOLUTION

2.990

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-024-07569-9

PUBLICATION DATE

July 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
aristolochic acid A100 3.43x43 TM3 Van der Waals
aristolochic acid A100 3.43x43 TM3 polar (hydrogen bond with backbone)
aristolochic acid G104 3.47x47 TM3 Van der Waals
aristolochic acid Y107 3.50x50 TM3 Van der Waals
aristolochic acid Y107 3.50x50 TM3 aromatic (edge-to-face)
aristolochic acid F108 3.51x51 TM3 Van der Waals
aristolochic acid S194 5.54x54 TM5 polar (hydrogen bond)
aristolochic acid S194 5.54x54 TM5 Van der Waals
aristolochic acid M197 5.57x57 TM5 Van der Waals
aristolochic acid F198 5.58x58 TM5 Van der Waals
aristolochic acid F198 5.58x58 TM5 aromatic (edge-to-face)
aristolochic acid F198 5.58x58 TM5 polar (hydrogen bond with backbone)
aristolochic acid L201 5.61x61 TM5 Van der Waals
aristolochic acid L201 5.61x61 TM5 hydrophobic
aristolochic acid G229 6.34x34 TM6 Van der Waals
aristolochic acid V233 6.38x38 TM6 hydrophobic
aristolochic acid V233 6.38x38 TM6 Van der Waals
aristolochic acid F237 6.42x42 TM6 hydrophobic
aristolochic acid F237 6.42x42 TM6 Van der Waals
aristolochic acid H276 7.49x49 TM7 polar (charge-assisted hydrogen bond)
aristolochic acid H276 7.49x49 TM7 polar (hydrogen bond)
aristolochic acid H276 7.49x49 TM7 polar (charge-assisted hydrogen bond)
aristolochic acid H276 7.49x49 TM7 polar (hydrogen bond)
aristolochic acid L280 7.53x53 TM7 Van der Waals

Ligands

aristolochic acid

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Residue Diagrams

S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7
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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x43 3.43x43 A100
3x47 3.47x47 G104
3x50 3.50x50 Y107
3x51 3.51x51 F108
TM5
5x54 5.54x54 S194
5x57 5.57x57 M197
5x58 5.58x58 F198
5x61 5.61x61 L201
TM6
6x34 6.34x34 G229
6x38 6.38x38 V233
6x42 6.42x42 F237
TM7
7x49 7.49x49 H276
7x53 7.53x53 L280