Structure information

TAS2R14

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

8XQO

SPECIES

Homo sapiens

RESOLUTION

2.770

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-024-07569-9

PUBLICATION DATE

July 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
aristolochic acid Y107 3.50x50 TM3 aromatic (edge-to-face)
aristolochic acid F198 5.58x58 TM5 aromatic (edge-to-face)
aristolochic acid F198 5.58x58 TM5 Van der Waals
aristolochic acid F198 5.58x58 TM5 polar (hydrogen bond with backbone)
aristolochic acid L201 5.61x61 TM5 hydrophobic
aristolochic acid L201 5.61x61 TM5 Van der Waals
aristolochic acid G229 6.34x34 TM6 Van der Waals
aristolochic acid V230 6.35x35 TM6 hydrophobic
aristolochic acid V230 6.35x35 TM6 Van der Waals
aristolochic acid V233 6.38x38 TM6 hydrophobic
aristolochic acid V233 6.38x38 TM6 Van der Waals
aristolochic acid F237 6.42x42 TM6 hydrophobic
aristolochic acid F237 6.42x42 TM6 Van der Waals
aristolochic acid H276 7.49x49 TM7 polar (hydrogen bond)
aristolochic acid G283 7.56x56 TM7 Van der Waals

Ligands

aristolochic acid

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Residue Diagrams

S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7
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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x50 3.50x50 Y107
TM5
5x58 5.58x58 F198
5x61 5.61x61 L201
TM6
6x34 6.34x34 G229
6x35 6.35x35 V230
6x38 6.38x38 V233
6x42 6.42x42 F237
TM7
7x49 7.49x49 H276
7x56 7.56x56 G283