Structure information

TAS2R14

PROTEIN CLASS

Class T2 (Taste 2)

PDB CODE

8XQS

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-024-07569-9

PUBLICATION DATE

July 10, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
flufenamic acid Y107 3.50x50 TM3 hydrophobic
flufenamic acid F198 5.58x58 TM5 aromatic (edge-to-face)
flufenamic acid F237 6.42x42 TM6 hydrophobic
flufenamic acid H276 7.49x49 TM7 polar (hydrogen bond)
flufenamic acid H276 7.49x49 TM7 Van der Waals

Ligands

flufenamic acid

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Residue Diagrams

S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7
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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
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Residue Table


GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x50 3.50x50 Y107
TM5
5x58 5.58x58 F198
TM6
6x42 6.42x42 F237
TM7
7x49 7.49x49 H276