Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XZH

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2024.02.004

PUBLICATION DATE

March 20, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MM07 W85 2.60x60 TM2 hydrophobic
MM07 Y93 ECL1 hydrophobic
MM07 S106 3.29x29 TM3 Van der Waals
MM07 S106 3.29x29 TM3 polar (hydrogen bond)
MM07 I109 3.32x32 TM3 hydrophobic
MM07 I109 3.32x32 TM3 Van der Waals
MM07 F110 3.33x33 TM3 Van der Waals
MM07 F110 3.33x33 TM3 hydrophobic
MM07 V164 4.60x61 TM4 hydrophobic
MM07 V164 4.60x61 TM4 Van der Waals
MM07 R168 4.64x65 TM4 polar (charge-assisted hydrogen bond)
MM07 C181 45.50x50 ECL2 Van der Waals
MM07 Y182 45.51x51 ECL2 hydrophobic
MM07 Y182 45.51x51 ECL2 Van der Waals
MM07 M183 45.52x52 ECL2 Van der Waals
MM07 M183 45.52x52 ECL2 polar (hydrogen bond with backbone)
MM07 Y185 ECL2 Van der Waals
MM07 E194 5.31x32 TM5 Van der Waals
MM07 W195 5.32x33 TM5 Van der Waals
MM07 W195 5.32x33 TM5 hydrophobic
MM07 E198 5.35x36 TM5 Van der Waals
MM07 L201 5.38x39 TM5 Van der Waals
MM07 L201 5.38x39 TM5 hydrophobic
MM07 Y264 6.51x51 TM6 hydrophobic
MM07 Y264 6.51x51 TM6 Van der Waals
MM07 K268 6.55x55 TM6 Van der Waals
MM07 Y271 6.58x58 TM6 Van der Waals
MM07 Y271 6.58x58 TM6 hydrophobic
MM07 S275 6.62x62 TM6 Van der Waals
MM07 F291 7.35x34 TM7 hydrophobic
MM07 F291 7.35x34 TM7 Van der Waals
MM07 Y299 7.43x42 TM7 Van der Waals

Ligands

MM07

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
TM3
3x29 3.29x29 S106
3x32 3.32x32 I109
3x33 3.33x33 F110
TM4
4x61 4.60x61 V164
4x65 4.64x65 R168
ECL2
45x50 45.50x50 C181
45x51 45.51x51 Y182
45x52 45.52x52 M183
TM5
5x32 5.31x32 E194
5x33 5.32x33 W195
5x36 5.35x36 E198
5x39 5.38x39 L201
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
6x62 6.62x62 S275
TM7
7x34 7.35x34 F291
7x42 7.43x42 Y299