Structure information

BB3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8Y52

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2024.114511

PUBLICATION DATE

Sept. 11, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Bombesin L96 2.53x53 TM2 hydrophobic
Bombesin T106 2.63x62 TM2 polar (hydrogen bond with backbone)
Bombesin T106 2.63x62 TM2 Van der Waals
Bombesin H107 2.64x63 TM2 Van der Waals
Bombesin H107 2.64x63 TM2 polar (hydrogen bond with backbone)
Bombesin Y108 2.65x64 TM2 hydrophobic
Bombesin Y108 2.65x64 TM2 Van der Waals
Bombesin E111 ECL1 Van der Waals
Bombesin G112 23.49x49 ECL1 Van der Waals
Bombesin G112 23.49x49 ECL1 polar (hydrogen bond with backbone)
Bombesin W113 23.50x50 ECL1 polar (hydrogen bond with backbone)
Bombesin W113 23.50x50 ECL1 Van der Waals
Bombesin S124 3.29x29 TM3 polar (hydrogen bond)
Bombesin R127 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Bombesin V131 3.36x36 TM3 Van der Waals
Bombesin V131 3.36x36 TM3 hydrophobic
Bombesin E182 4.60x61 TM4 polar (charge-assisted hydrogen bond)
Bombesin F200 ECL2 Van der Waals
Bombesin E201 ECL2 Van der Waals
Bombesin E201 ECL2 polar (hydrogen bond with backbone)
Bombesin S202 ECL2 Van der Waals
Bombesin C203 45.50x50 ECL2 Van der Waals
Bombesin T204 45.51x51 ECL2 Van der Waals
Bombesin S205 45.52x52 ECL2 Van der Waals
Bombesin W284 6.48x48 TM6 hydrophobic
Bombesin W284 6.48x48 TM6 Van der Waals
Bombesin N287 6.51x51 TM6 Van der Waals
Bombesin H288 6.52x52 TM6 Van der Waals
Bombesin H288 6.52x52 TM6 aromatic (face-to-edge)
Bombesin Y291 6.55x55 TM6 aromatic (face-to-edge)
Bombesin Y291 6.55x55 TM6 Van der Waals
Bombesin H294 6.58x58 TM6 Van der Waals
Bombesin D303 ECL3 Van der Waals
Bombesin P304 ECL3 Van der Waals
Bombesin S305 ECL3 Van der Waals
Bombesin H308 7.31x30 TM7 Van der Waals
Bombesin F309 7.32x31 TM7 aromatic (edge-to-face)
Bombesin F309 7.32x31 TM7 Van der Waals
Bombesin T312 7.35x34 TM7 Van der Waals
Bombesin R316 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Bombesin A319 7.42x41 TM7 Van der Waals
Bombesin A319 7.42x41 TM7 hydrophobic

Ligands

Bombesin

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Residue Diagrams

A N G L I G V S I I V A Y T I Y I A C L 1 T S L A F G D L L L L T L C V P V D A T H 2 I T L T F V S V G V S T L R I F S L V K 3 T C V K A G C V W I V S M I F A L P E 4 Y Y V S I I S L P I I Y F V L F C L L S H 5 L V L V A L F A L C W L P N H L L Y L Y 6 F P N V C S N S F A L V R S F I T F I 7
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ICL1 K S M Q ICL1ECL1 E G W L F ECL1ICL2 P L E R Q P S N ICL2ECL2 N V Y T F R D P N K N M T F E S C T S Y P V S ECL2ICL3 P T E E Q S ICL3ECL3 Q T Y V D P ECL3N-term M A Q R Q P H S P N Q T L I S I T N D T E S S S S V V S N D N T N K G W S G D N S P G N-termC-term C C K A E R P E P P V A D T S L T T L A V M G T V P G T G S I Q M S E I S V T S F T G C S V K Q A E D R F C-term I E A L C A I Y I T Y A V I I S V G I L G N A I L I K V F F K T T V P N I F I T S L A F G D L L L L L T C V P V D A T H Y L A G R I G C K V L S F I R L T S V G V S V F T L T I L S A D R Y K A V V K A I L K T C V K A G C V W I V S M I F A L P E A I F S K K L L Q E I H S L L C F L V F Y I I P L S I I S V Y Y S L I A R T L Y K S T L N I H A R K Q I E S R K R I A R T V L V L V A L F A L C W L P N H L L Y L Y H S F T S S A M H F I F T I F S R V L A F S N S C V N P F A L Y W L S K S F K A F Q K H Q L F
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Residue Table


GPCRdb(A)
GPCRdb(A)
BB3 receptor
TM2
2x53 2.53x53 L96
2x62 2.63x62 T106
2x63 2.64x63 H107
2x64 2.65x64 Y108
ECL1
23x49 23.49x49 G112
23x50 23.50x50 W113
TM3
3x29 3.29x29 S124
3x32 3.32x32 R127
3x36 3.36x36 V131
TM4
4x61 4.60x61 E182
ECL2
45x50 45.50x50 C203
45x51 45.51x51 T204
45x52 45.52x52 S205
TM6
6x48 6.48x48 W284
6x51 6.51x51 N287
6x52 6.52x52 H288
6x55 6.55x55 Y291
6x58 6.58x58 H294
TM7
7x30 7.31x30 H308
7x31 7.32x31 F309
7x34 7.35x34 T312
7x38 7.39x38 R316
7x41 7.42x41 A319