PDB
8Y73
Resolution
2.8 Å
Released
Aug. 6, 2025
Receptor
μ
Class
A
Species
Homo sapiens
Ligands
Function
DAMGO
Agonist
MPAM-15
PAM
Reference
—
DAMGO MPAM-15

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Ligand Amino Acid Generic Number Segment Interaction Type
MPAM-15 L118 2.52x52 TM2 hydrophobic
DAMGO Q126 2.60x60 TM2 hydrophobic
DAMGO N129 2.63x63 TM2 Van der Waals
DAMGO W135 23.50x50 ECL1 aromatic (edge-to-face)
DAMGO W135 23.50x50 ECL1 hydrophobic
MPAM-15 I144 3.27x27 TM3 Van der Waals
DAMGO V145 3.28x28 TM3 hydrophobic
DAMGO I146 3.29x29 TM3 hydrophobic
MPAM-15 S147 3.30x30 TM3 Van der Waals
MPAM-15 I148 3.31x31 TM3 hydrophobic
DAMGO D149 3.32x32 TM3 polar (charge-charge)
DAMGO Y150 3.33x33 TM3 aromatic (pi-cation)
MPAM-15 Y151 3.34x34 TM3 hydrophobic
MPAM-15 N152 3.35x35 TM3 polar (hydrogen bond)
DAMGO M153 3.36x36 TM3 hydrophobic
MPAM-15 W194 4.50x50 TM4 hydrophobic
MPAM-15 S198 4.54x54 TM4 Van der Waals
MPAM-15 G201 4.57x57 TM4 Van der Waals
MPAM-15 L202 4.58x58 TM4 hydrophobic
MPAM-15 M205 4.61x61 TM4 hydrophobic
DAMGO C219 45.50x50 ECL2 hydrophobic
DAMGO T220 45.51x51 ECL2 Van der Waals
DAMGO K235 5.39x40 TM5 Van der Waals
DAMGO V238 5.42x43 TM5 hydrophobic
DAMGO W295 6.48x48 TM6 Van der Waals
DAMGO I298 6.51x51 TM6 Van der Waals
DAMGO H299 6.52x52 TM6 Van der Waals
DAMGO V302 6.55x55 TM6 Van der Waals
DAMGO W320 7.35x34 TM7 Van der Waals
DAMGO I324 7.39x38 TM7 Van der Waals
DAMGO Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x52 2.52x52 L118
2x60 2.60x60 Q126
2x63 2.63x63 N129
ECL1
23x50 23.50x50 W135
TM3
3x27 3.27x27 I144
3x28 3.28x28 V145
3x29 3.29x29 I146
3x30 3.30x30 S147
3x31 3.31x31 I148
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x34 3.34x34 Y151
3x35 3.35x35 N152
3x36 3.36x36 M153
TM4
4x50 4.50x50 W194
4x54 4.54x54 S198
4x57 4.57x57 G201
4x58 4.58x58 L202
4x61 4.61x61 M205
ECL2
45x50 45.50x50 C219
45x51 45.51x51 T220
TM5
5x40 5.39x40 K235
5x43 5.42x43 V238
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328