Structure information

H3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8YUU

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1002/ADVS.202310120

PUBLICATION DATE

June 5, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
histamine D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
histamine Y115 3.33x33 TM3 hydrophobic
histamine Y115 3.33x33 TM3 Van der Waals
histamine C118 3.36x36 TM3 Van der Waals
histamine F398 7.39x38 TM7 polar (hydrogen bond with backbone)
histamine F398 7.39x38 TM7 Van der Waals
histamine L401 7.42x41 TM7 hydrophobic
histamine L401 7.42x41 TM7 Van der Waals
histamine W402 7.43x42 TM7 aromatic (face-to-edge)
histamine W402 7.43x42 TM7 Van der Waals

Ligands

histamine

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Residue Diagrams

A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7
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ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 Y115
3x36 3.36x36 C118
TM7
7x38 7.39x38 F398
7x41 7.42x41 L401
7x42 7.43x42 W402