Structure information

H3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8YUV

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

June 5, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
immepip D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
immepip D114 3.32x32 TM3 polar (hydrogen bond with backbone)
immepip Y115 3.33x33 TM3 polar (hydrogen bond with backbone)
immepip Y115 3.33x33 TM3 Van der Waals
immepip C118 3.36x36 TM3 polar (hydrogen bond)
immepip T119 3.37x37 TM3 polar (hydrogen bond)
immepip T119 3.37x37 TM3 polar (hydrogen bond with backbone)
immepip Y167 4.57x57 TM4 Van der Waals
immepip E206 5.46x461 TM5 polar (charge-assisted hydrogen bond)
immepip W371 6.48x48 TM6 Van der Waals
immepip Y374 6.51x51 TM6 aromatic (face-to-edge)
immepip Y374 6.51x51 TM6 polar (hydrogen bond)
immepip F398 7.39x38 TM7 polar (hydrogen bond with backbone)
immepip F398 7.39x38 TM7 Van der Waals
immepip L401 7.42x41 TM7 hydrophobic
immepip L401 7.42x41 TM7 Van der Waals
immepip W402 7.43x42 TM7 polar (hydrogen bond)
immepip W402 7.43x42 TM7 aromatic (face-to-edge)

Ligands

immepip

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Residue Diagrams

A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7
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ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 Y115
3x36 3.36x36 C118
3x37 3.37x37 T119
TM4
4x57 4.57x57 Y167
TM5
5x461 5.46x461 E206
TM6
6x48 6.48x48 W371
6x51 6.51x51 Y374
TM7
7x38 7.39x38 F398
7x41 7.42x41 L401
7x42 7.43x42 W402