Structure information

kisspeptin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZJD

SPECIES

Homo sapiens

RESOLUTION

3.060

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Kisspeptin-10 F98 2.60x59 TM2 hydrophobic
Kisspeptin-10 L101 2.63x62 TM2 Van der Waals
Kisspeptin-10 L101 2.63x62 TM2 polar (hydrogen bond with backbone)
Kisspeptin-10 L102 2.64x63 TM2 hydrophobic
Kisspeptin-10 L102 2.64x63 TM2 Van der Waals
Kisspeptin-10 L105 ECL1 polar (hydrogen bond with backbone)
Kisspeptin-10 L105 ECL1 Van der Waals
Kisspeptin-10 P106 ECL1 hydrophobic
Kisspeptin-10 P106 ECL1 Van der Waals
Kisspeptin-10 G107 23.49x49 ECL1 Van der Waals
Kisspeptin-10 G107 23.49x49 ECL1 polar (hydrogen bond with backbone)
Kisspeptin-10 W108 23.50x50 ECL1 Van der Waals
Kisspeptin-10 V118 3.28x28 TM3 Van der Waals
Kisspeptin-10 V118 3.28x28 TM3 hydrophobic
Kisspeptin-10 N119 3.29x29 TM3 Van der Waals
Kisspeptin-10 Q122 3.32x32 TM3 polar (hydrogen bond)
Kisspeptin-10 Q122 3.32x32 TM3 polar (hydrogen bond)
Kisspeptin-10 Q123 3.33x33 TM3 polar (hydrogen bond)
Kisspeptin-10 Q123 3.33x33 TM3 Van der Waals
Kisspeptin-10 V126 3.36x36 TM3 Van der Waals
Kisspeptin-10 V126 3.36x36 TM3 hydrophobic
Kisspeptin-10 H181 ECL2 Van der Waals
Kisspeptin-10 Y190 ECL2 hydrophobic
Kisspeptin-10 Y190 ECL2 Van der Waals
Kisspeptin-10 C191 45.50x50 ECL2 Van der Waals
Kisspeptin-10 F204 5.38x39 TM5 Van der Waals
Kisspeptin-10 N208 5.42x43 TM5 Van der Waals
Kisspeptin-10 I279 6.51x51 TM6 Van der Waals
Kisspeptin-10 I279 6.51x51 TM6 hydrophobic
Kisspeptin-10 L283 6.55x55 TM6 Van der Waals
Kisspeptin-10 L283 6.55x55 TM6 hydrophobic
Kisspeptin-10 P296 ECL3 Van der Waals
Kisspeptin-10 R297 ECL3 Van der Waals
Kisspeptin-10 R297 ECL3 polar (hydrogen bond with backbone)
Kisspeptin-10 S298 7.28x27 TM7 Van der Waals
Kisspeptin-10 Y299 7.29x28 TM7 hydrophobic
Kisspeptin-10 Y299 7.29x28 TM7 Van der Waals
Kisspeptin-10 A301 7.31x30 TM7 hydrophobic
Kisspeptin-10 Y302 7.32x31 TM7 hydrophobic
Kisspeptin-10 Y302 7.32x31 TM7 Van der Waals
Kisspeptin-10 K305 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Kisspeptin-10 H309 7.39x38 TM7 polar (hydrogen bond)
Kisspeptin-10 H309 7.39x38 TM7 Van der Waals
Kisspeptin-10 Y313 7.43x42 TM7 polar (hydrogen bond)
Kisspeptin-10 Y313 7.43x42 TM7 Van der Waals

Ligands

Kisspeptin-10

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Residue Diagrams

S N G V L G L L M L A A F F L P V L W A 1 A N L A A T D V T F L C L C V P F T A L L 2 A T L T A C T A Q V S V Q Q I Y N V F K 3 A L A V S L S I W V G S A A V S A P V 4 Y C A C T A L L P L L Y L A L L N Y L A F 5 A A V V L L F A A C W G P I Q L F L V L 6 L P N L A S N S Y S M C H A W T K L A 7
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ICL1 K P M R ICL1ECL1 P L P G W V L ECL1ICL2 P L R A L H R R ICL2ECL2 R L S P G P R A Y C S E A F P ECL2ECL3 P A G S W H P R ECL3N-term M H T V A T S G P N A S W G A P A N A S G C P G C G A N A S D G P V P S P R N-termC-term C A P R R P R R P R R P G P S D P A A P H A E L L R L G S H P A P A R A Q K P G S S G L A A R G L C V L G E D N A P L C-term A V D A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y G D F M C K F V N Y I Q Q V S V Q A T C A T L T A M S V D R W Y V T V F T P R L A L A V S L S I W V G S A A V S A P V L A L H S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V A V R P A P A D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R R F R Q A V C P
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Residue Table


GPCRdb(A)
GPCRdb(A)
kisspeptin receptor
TM2
2x59 2.60x59 F98
2x62 2.63x62 L101
2x63 2.64x63 L102
ECL1
23x49 23.49x49 G107
23x50 23.50x50 W108
TM3
3x28 3.28x28 V118
3x29 3.29x29 N119
3x32 3.32x32 Q122
3x33 3.33x33 Q123
3x36 3.36x36 V126
ECL2
45x50 45.50x50 C191
TM5
5x39 5.38x39 F204
5x43 5.42x43 N208
TM6
6x51 6.51x51 I279
6x55 6.55x55 L283
TM7
7x27 7.28x27 S298
7x28 7.29x28 Y299
7x30 7.31x30 A301
7x31 7.32x31 Y302
7x34 7.35x34 K305
7x38 7.39x38 H309
7x42 7.43x42 Y313