Structure information

PrRP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZPS

SPECIES

Homo sapiens

RESOLUTION

2.970

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00724-6

PUBLICATION DATE

Sept. 25, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Prolactin-releasing peptide PrRP20 Q54 N-term Van der Waals
Prolactin-releasing peptide PrRP20 Q54 N-term polar (hydrogen bond with backbone)
Prolactin-releasing peptide PrRP20 C113 2.57x56 TM2 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 T117 2.61x60 TM2 Van der Waals
Prolactin-releasing peptide PrRP20 Y120 2.64x63 TM2 Van der Waals
Prolactin-releasing peptide PrRP20 A121 2.65x64 TM2 hydrophobic
Prolactin-releasing peptide PrRP20 A121 2.65x64 TM2 Van der Waals
Prolactin-releasing peptide PrRP20 Q141 3.32x32 TM3 Van der Waals
Prolactin-releasing peptide PrRP20 Q141 3.32x32 TM3 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 P142 3.33x33 TM3 Van der Waals
Prolactin-releasing peptide PrRP20 P142 3.33x33 TM3 hydrophobic
Prolactin-releasing peptide PrRP20 V145 3.36x36 TM3 hydrophobic
Prolactin-releasing peptide PrRP20 V145 3.36x36 TM3 Van der Waals
Prolactin-releasing peptide PrRP20 Y146 3.37x37 TM3 Van der Waals
Prolactin-releasing peptide PrRP20 Y146 3.37x37 TM3 hydrophobic
Prolactin-releasing peptide PrRP20 Y199 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 Y199 ECL2 hydrophobic
Prolactin-releasing peptide PrRP20 P205 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 H206 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 V208 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 L210 ECL2 hydrophobic
Prolactin-releasing peptide PrRP20 L210 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 E212 45.51x51 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 E213 45.52x52 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 F214 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 Y225 5.38x39 TM5 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 L229 5.42x43 TM5 Van der Waals
Prolactin-releasing peptide PrRP20 L294 6.51x51 TM6 Van der Waals
Prolactin-releasing peptide PrRP20 N298 6.55x55 TM6 Van der Waals
Prolactin-releasing peptide PrRP20 R301 6.58x58 TM6 Van der Waals
Prolactin-releasing peptide PrRP20 D302 6.59x59 TM6 Van der Waals
Prolactin-releasing peptide PrRP20 P310 7.28x27 TM7 Van der Waals
Prolactin-releasing peptide PrRP20 P310 7.28x27 TM7 hydrophobic
Prolactin-releasing peptide PrRP20 F313 7.31x30 TM7 Van der Waals
Prolactin-releasing peptide PrRP20 Q317 7.35x34 TM7 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 Q317 7.35x34 TM7 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 L318 7.36x35 TM7 hydrophobic
Prolactin-releasing peptide PrRP20 L318 7.36x35 TM7 Van der Waals
Prolactin-releasing peptide PrRP20 H321 7.39x38 TM7 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 H321 7.39x38 TM7 Van der Waals

Ligands

Prolactin-releasing peptide PrRP20

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Residue Diagrams

C N G V L G V V V V V S Y L L V I L G K 1 G N L A L S D V L M C A T C V P L T L A Y 2 T T L T F V S V Y V T V P Q L F F V L H 3 S A Y A V L A I W A L S A V L A L P A 4 Y S L L I V L L P L L Y T V L L L G W A Y 5 V V I V V V F A V C W L P L H V F N L L 6 F P N Y C A S S M A L W H C L L Q V L 7
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ICL1 R R L H ICL1ECL1 R G W V F ECL1ICL2 P L R R R I ICL2ECL2 Y H V E L K P H D V R L C E E F W G S Q ECL2ICL3 V T Q S Q ICL3ECL3 P H A I ECL3N-term M A S S T T R G P R V S D L F S G L P P A V T T P A N Q S A E A S A G N G S V A G A D A P A V T P F Q S L Q L V H Q N-termC-term K I A P H G Q N M T V S V V I C-term L K G L I V L L Y S V V V V V G L V G N C L L V L V I A R V N V T N F L I G N L A L S D V L M C T A C V P L T L A Y A F E P G G G L C H L V F F L Q P V T V Y V S V F T L T T I A V D R Y V V L V H S L R L S A Y A V L A I W A L S A V L A L P A A V H T E R Q R Q L Y A W G L L L V T Y L L P L L V I L L S Y V R V S V K L R N R V V P G C A D W D R A R R R R T F C L L V V I V V V F A V C W L P L H V F N L L R D L D D P Y A F G L V Q L L C H W L A M S S A C Y N P F I Y A W L H D S L R K W P R F R E E L L V A
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Residue Table


GPCRdb(A)
GPCRdb(A)
PrRP receptor
TM2
2x56 2.57x56 C113
2x60 2.61x60 T117
2x63 2.64x63 Y120
2x64 2.65x64 A121
TM3
3x32 3.32x32 Q141
3x33 3.33x33 P142
3x36 3.36x36 V145
3x37 3.37x37 Y146
ECL2
45x51 45.51x51 E212
45x52 45.52x52 E213
TM5
5x39 5.38x39 Y225
5x43 5.42x43 L229
TM6
6x51 6.51x51 L294
6x55 6.55x55 N298
6x58 6.58x58 R301
6x59 6.59x59 D302
TM7
7x27 7.28x27 P310
7x30 7.31x30 F313
7x34 7.35x34 Q317
7x35 7.36x35 L318
7x38 7.39x38 H321