Structure information

PrRP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZPT

SPECIES

Homo sapiens

RESOLUTION

2.960

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00724-6

PUBLICATION DATE

Sept. 25, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Prolactin-releasing peptide PrRP20 L55 N-term hydrophobic
Prolactin-releasing peptide PrRP20 T117 2.61x60 TM2 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 Y120 2.64x63 TM2 hydrophobic
Prolactin-releasing peptide PrRP20 Y120 2.64x63 TM2 Van der Waals
Prolactin-releasing peptide PrRP20 Q141 3.32x32 TM3 Van der Waals
Prolactin-releasing peptide PrRP20 P142 3.33x33 TM3 hydrophobic
Prolactin-releasing peptide PrRP20 P142 3.33x33 TM3 Van der Waals
Prolactin-releasing peptide PrRP20 E212 45.51x51 ECL2 Van der Waals
Prolactin-releasing peptide PrRP20 E213 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Prolactin-releasing peptide PrRP20 L294 6.51x51 TM6 hydrophobic
Prolactin-releasing peptide PrRP20 N298 6.55x55 TM6 Van der Waals
Prolactin-releasing peptide PrRP20 R301 6.58x58 TM6 Van der Waals
Prolactin-releasing peptide PrRP20 P305 ECL3 Van der Waals
Prolactin-releasing peptide PrRP20 Q317 7.35x34 TM7 polar (hydrogen bond)
Prolactin-releasing peptide PrRP20 Q317 7.35x34 TM7 Van der Waals
Prolactin-releasing peptide PrRP20 H321 7.39x38 TM7 Van der Waals

Ligands

Prolactin-releasing peptide PrRP20

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Residue Diagrams

C N G V L G V V V V V S Y L L V I L G K 1 G N L A L S D V L M C A T C V P L T L A Y 2 T T L T F V S V Y V T V P Q L F F V L H 3 S A Y A V L A I W A L S A V L A L P A 4 Y S L L I V L L P L L Y T V L L L G W A Y 5 V V I V V V F A V C W L P L H V F N L L 6 F P N Y C A S S M A L W H C L L Q V L 7
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ICL1 R R L H ICL1ECL1 R G W V F ECL1ICL2 P L R R R I ICL2ECL2 Y H V E L K P H D V R L C E E F W G S Q ECL2ICL3 V T Q S Q ICL3ECL3 P H A I ECL3N-term M A S S T T R G P R V S D L F S G L P P A V T T P A N Q S A E A S A G N G S V A G A D A P A V T P F Q S L Q L V H Q N-termC-term K I A P H G Q N M T V S V V I C-term L K G L I V L L Y S V V V V V G L V G N C L L V L V I A R V N V T N F L I G N L A L S D V L M C T A C V P L T L A Y A F E P G G G L C H L V F F L Q P V T V Y V S V F T L T T I A V D R Y V V L V H S L R L S A Y A V L A I W A L S A V L A L P A A V H T E R Q R Q L Y A W G L L L V T Y L L P L L V I L L S Y V R V S V K L R N R V V P G C A D W D R A R R R R T F C L L V V I V V V F A V C W L P L H V F N L L R D L D D P Y A F G L V Q L L C H W L A M S S A C Y N P F I Y A W L H D S L R K W P R F R E E L L V A
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Residue Table


GPCRdb(A)
GPCRdb(A)
PrRP receptor
TM2
2x60 2.61x60 T117
2x63 2.64x63 Y120
TM3
3x32 3.32x32 Q141
3x33 3.33x33 P142
ECL2
45x51 45.51x51 E212
45x52 45.52x52 E213
TM6
6x51 6.51x51 L294
6x55 6.55x55 N298
6x58 6.58x58 R301
TM7
7x34 7.35x34 Q317
7x38 7.39x38 H321